Microgest 200 mg (Capsule)

Indications

• Maintenance of Pregnancy in cases of Threatened / Recurrent abortion
• Luteal support during IUI and ART procedures IVF-ET
• Luteal support in cases of proven luteal phase insufficiency
• Post-menopausal hormone replacement therapy (HRT)
• Prevention of endometrial hyperplasia
• Progesterone challenge test in secondary amenorrhoea
• Cycle control along with estrogen therapy
• Dysfunctional uterine bleeding (DUB)
• Premenstrual tension
• Endometriosis
• Oocyte donation programme
• Benign mastopathy

Pharmacology

• Structurally and biologically identical to natural endogenous progesterone
• Increased bioavailability with micronisation
• High progesterone concentrations in endometrial and breast tissue
• Metabolized to pregnanediols and pregnanolones
• Excretion via bile and urine
• Enterohepatic circulation potential

Dosage & Administration

• Recommended dose of Progesterone 100 mg/200 mg 2 to 3 soft gel capsules daily
• Flexible dosing based on indication and patient requirements
• Specific dosing for various indications like Maintenance of Pregnancy, HRT, Luteal support, etc.

Interaction

• Inhibition of progesterone metabolism by Ketoconazole

Contraindications

• Hypersensitivity
• Hepatic dysfunction
• Undiagnosed vaginal bleeding
• Porphyria
• Cancers of uterus and genital organs
• Breast cancers
• History of stroke or blood clots
• Not for use in case of miscarriage

Side Effects

• Devoid of estrogenic, androgenic, mineralocorticoid effects
• CNS side effects like mild somnolence, depression, breast tenderness, bloating
• Reduced side effects with vaginal route administration

Precautions & Warnings

• Severe renal insufficiency
• Diabetes mellitus
• Seizures
• Migraine
• Headache
• Heart diseases
• Depression

Therapeutic Class

• Drugs for menopausal symptoms
• Hormone replacement therapy
• Female Sex hormones
• Oral Contraceptive preparations

Storage Conditions

• Store below 30°C
• Away from light and moisture
• Keep out of reach of children

Related Brands

• Microgest 100 mg (Capsule) - renata-limited