Omnitrope 5 mg/1.5 ml (SC Injection)
1 Kit Pen: ৳ 20,809.68
Medicine Details
| Category | Details |
|---|---|
| Generic | Somatropin |
| Company | Sandoz a novartis division |
| Also available as |
Indications
- Treatment of pediatric patients with growth failure due to inadequate secretion of endogenous growth hormone (GH)
- Treatment of pediatric patients with short stature associated with Noonan syndrome
- Treatment of pediatric patients with short stature associated with Turner syndrome
- Treatment of pediatric patients with short stature born small for gestational age (SGA) with no catch-up growth by age 2 to 4 years
- Replacement of endogenous GH in adults with growth hormone deficiency (GHD)
Pharmacology
- Somatropin binds to a dimeric GH receptor in the cell membrane
- Results in intracellular signal transduction and pharmacodynamic effects
- Produces IGF-I in the liver and locally (e.g., skeletal growth, protein synthesis)
- Direct effects of somatropin (e.g., lipolysis)
Dosage & Administration
- Administered subcutaneously
- Injection sites should be rotated to avoid lipoatrophy
- Specific dosages for pediatric growth hormone deficiency, Noonan Syndrome, Turner Syndrome, short stature born small for gestational age (SGA), and adult growth hormone deficiency
Interaction
- Inhibition of 11-Hydroxysteroid Dehydrogenase Type 1 may require glucocorticoid replacement therapy
- Glucocorticoid Replacement should be carefully adjusted
- Monitor carefully when used with Cytochrome P450-Metabolized Drugs
- Larger doses may be required in women using Oral Estrogen
- Insulin and/or Oral/Injectable Hypoglycemic Agents may require adjustment
Contraindications
- Acute Critical Illness
- Children with Prader-Willi syndrome who are severely obese or have severe respiratory impairment
- Active Malignancy
- Hypersensitivity to somatropin or excipients
- Active Proliferative or Severe Non-Proliferative Diabetic Retinopathy
- Children with closed epiphyses
Side Effects
- Headaches
- Muscle pain
- Joint stiffness
- High blood sugar (hyperglycemia)
- Sugar in urine (glucosuria)
Pregnancy & Lactation
- Pregnancy Category C
- No animal reproduction studies conducted with Somatropin
- Caution when administered to a pregnant or nursing woman
Precautions & Warnings
- Potential benefit of treatment continuation in Acute Critical Illness should be weighed against potential risk
- Evaluation for signs of upper airway obstruction and sleep apnea in children with Prader-Willi Syndrome
- Monitoring preexisting tumors for progression or recurrence
- Unmasking of Impaired Glucose Tolerance and Diabetes Mellitus
- Exclusion of preexisting papilledema for Intracranial Hypertension
- Monitoring for reduced serum cortisol levels in Hypoadrenalism
- Evaluating children for the onset of a limp or hip/knee pain to detect Slipped Capital Femoral Epiphysis
- Considering pancreatitis in patients with persistent severe abdominal pain
Therapeutic Class
- Drugs for Growth failure
Storage Conditions
- Store at 2-8°C
- Do not freeze
- Avoid direct light
- Keep out of reach of children