Danzol 100 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Danazol |
| Company | Renata limited |
| Also available as |
Title
Danzol Medicine
Categories
- Medicine
- Healthcare
- Women's Health
Description
Danzol is indicated for the treatment of endometriosis, benign breast disease, menorrhagia, gynecomastia, and preoperative thinning of the endometrium before hysteroscopic endometrial ablation. It works as a gonadotropin inhibitor, suppressing the pituitary-ovarian axis, reducing ovarian estrogen production, directly inhibiting ovarian steroidogenesis, and binding to androgen, progesterone, and glucocorticoid receptors. The dosage & administration, interactions, contraindications, side effects, precautions, and storage conditions need to be carefully considered. This medicine belongs to the therapeutic class of drugs affecting (inhibiting) gonadotrophin.
Indications
- Endometriosis
- Benign breast disease
- Menorrhagia
- Gynecomastia
- Preoperative thinning of endometrium
Pharmacology
- Gonadotropin inhibitor
- Pituitary-ovarian axis suppression
- Reduction of ovarian estrogen production
- Ovarian steroidogenesis inhibition
- Receptor binding
- Increased metabolic clearance rate of progesterone
Dosage & Administration
- Adults: 200-800 mg daily in up to 4 divided doses
- Children: Not used in children
Interaction
- Insulin
- Estrogens and progestogens
- Anticonvulsant therapy
- Antihypertensive therapy
- Cyclosporine
- Migraine therapy
Contraindications
- Pregnancy and breast-feeding
- Impaired hepatic, renal, or cardiac function
- Porphyria
- Thromboembolic disease
- Androgen-dependent tumor
- Abnormal vaginal bleeding
- Hypersensitivity to danazol
Side Effects
- Nausea
- Dizziness
- Skin reactions
- Mood changes
- Changes in libido
- Headache
- Menstrual disturbances
- Musculo-skeletal effects
- Androgenic effects
- Metabolic changes
- Thrombotic events
Pregnancy & Lactation
Not recommended during pregnancy or lactation due to the risk of virilization of a female fetus and potential effects on breast-feeding
Precautions & Warnings
- Cardiac, hepatic or renal impairment
- Polycythaemia
- Epilepsy
- Diabetes mellitus
- Hypertension
- Migraine
- Lipoprotein disorder
- History of thrombosis or thromboembolic disease
- Signs of virilization
Therapeutic Class
Drugs affecting (inhibiting) gonadotrophin
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children