Lozana 200 mg (Capsule)
Unit Price: ৳ 38.00 (3 x 10: ৳ 1,140.00)
Strip Price: ৳ 380.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Danazol |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Endometriosis
- Benign breast disease
- Menorrhagia
- Gynecomastia
- Preoperative thinning of the endometrium before hysteroscopic endometrial ablation
Pharmacology
- Gonadotropin inhibitor
- Pituitary-ovarian axis suppression
- Inhibition of pituitary gonadotropins output
- Suppression of ovarian estrogen production
- Suppression of ovarian function
- Androgen, progesterone, and glucocorticoid receptor binding
- Effect on steroid receptor sites in breast tissue
- Increase in the metabolic clearance rate of progesterone
Dosage & Administration
- Given in up to 4 divided doses
- Treatment should start during menstruation
- Daily doses ranging from 100mg to 800mg
- Adjusted to achieve amenorrhea
- Duration of treatment from 3-9 months
- Not recommended for use in children
Interaction
- Potential interaction with insulin
- Potential interaction with estrogens and progestogens
- Potential interaction with anticonvulsant therapy
- Potential interaction with antihypertensive therapy
- Potential interaction with cyclosporine
- Potential interaction with migraine therapy
Contraindications
- Pregnancy and breast-feeding
- Impaired hepatic, renal, or cardiac function
- Porphyria
- Thromboembolic disease
- Androgen-dependent tumor
- Abnormal vaginal bleeding that has not been fully investigated
- Hypersensitivity to danazol
Side Effects
- Nausea
- Dizziness
- Skin reactions including rashes, photosensitivity, and exfoliative dermatitis
- Fever
- Changes in libido
- Fatigue
- Headache
- Weight gain
- Menstrual disturbances
- Vaginal dryness and irritation
- Musculo-skeletal spasm
- Hair loss
- Androgenic effects including acne, oily skin, and hirsutism
- Temporary alteration in lipoproteins and other metabolic changes
- Thrombotic events
- Reversible erythrocytosis or polycythaemia
- Visual disturbances
Pregnancy & Lactation
- Risk of virilization of a female fetus
- Breast-feeding not recommended
Precautions & Warnings
- Cardiac, hepatic, or renal impairment
- Polycythaemia
- Epilepsy
- Diabetes mellitus
- Hypertension
- Migraine
- Lipoprotein disorder
- History of thrombosis or thromboembolic disease
Therapeutic Class
- Drugs affecting (inhibiting) gonadotrophin
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children