Danafil 50 mg (Tablet)

Unit Price: ৳ 30.09 (1 x 4: ৳ 120.36)
Strip Price: ৳ 120.36

Medicine Details

Category Details
Generic Sildenafil citrate
Company Nipro jmi pharma ltd

Therapeutic Class

  • Drugs for Erectile Dysfunction

Indications

  • Treatment of men with erectile dysfunction
  • Pulmonary arterial hypertension

Description

  • Selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)

Mechanism of Action

  • Inhibition of PDE5
  • Increased levels of cGMP
  • Smooth muscle relaxation
  • Inflow of blood into penile tissues

Pharmacology

  • Action of nitric oxide
  • Metabolism by hepatic enzymes
  • Rapid absorption after oral administration
  • Clearance in geriatric population

Dosage & Administration

  • Recommended dose of 50 mg for erectile dysfunction
  • Maximum recommended dose of 100 mg
  • Recommended dose of 20 mg for pulmonary arterial hypertension

Interaction

  • Metabolism by cytochrome P450 isoforms
  • Effects of CYP3A4 inhibitors
  • Effects of CYP3A4 inducers
  • Effect on drug pharmacokinetics

Contraindications

  • Hypersensitivity to any component
  • Concomitant use with nitrates

Side Effects

  • Body as a whole reactions
  • Cardiovascular effects
  • Digestive system effects
  • Hemic and Lymphatic effects
  • Metabolic and Nutritional effects
  • Musculoskeletal effects
  • Nervous system effects
  • Respiratory effects
  • Skin and Appendages reactions
  • Special Senses reactions
  • Urogenital reactions

Pregnancy & Lactation

  • Pregnancy category B
  • No indication for use in women
  • Animal study findings

Precautions & Warnings

  • Evaluating underlying causes of erectile dysfunction
  • Caution with alpha-blockers
  • Cardiac risk of sexual activity
  • Sensitivity in certain patient groups
  • Prolonged erection and priapism
  • Caution with ritonavir use

Overdose Effects

  • Similar adverse events to lower doses
  • Standard supportive measures recommended
  • Renal dialysis not expected to accelerate clearance

Storage Conditions

  • Keep in a dry place
  • Away from light and heat
  • Keep out of reach of children

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