Enegra 50 mg (Tablet)
Unit Price: ৳ 30.00 (1 x 4: ৳ 120.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sildenafil citrate |
| Company | Beximco pharmaceuticals ltd |
Indications
- Treatment of erectile dysfunction
- Treatment of pulmonary arterial hypertension
- Sexual stimulation required for effectiveness
Description
- Selective, reversible inhibitor of PDE5
- Increases levels of cGMP in corpus cavernosum
- Smooth muscle relaxation
- Inflow of blood into penile tissues
- No effect in absence of sexual stimulation
Pharmacology
- Mechanism of Action:
- Release of nitric oxide
- Activation of guanylate cyclase
- Increased levels of cGMP
- Smooth muscle relaxation in corpus cavernosum
- Inflow of blood
- Pharmacokinetics and Metabolism:
- Mean absolute bioavailability of 41%
- Eliminated predominantly by hepatic metabolism
- Terminal half lives of about 4 hours
- Absorption and Distribution:
- Rapid absorption
- Maximum plasma concentrations reached within 30 to 120 minutes
- Metabolism and Excretion:
- Clearance by hepatic microsomal isoenzymes
- Excretion as metabolites in feces and urine
- Pharmacokinetics in Special Populations:
- Reduced clearance in elderly volunteers
Dosage & Administration
- Recommended dose of 50 mg for erectile dysfunction
- Maximum recommended dosing frequency is once per day
- Recommended dose of 20 mg three times a day for pulmonary arterial hypertension
- Factors associated with increased plasma levels
Interaction
- Metabolism mediated by CYP isoforms
- Inhibitors and inducers affecting clearance
- Specific interactions with inhibitors and inducers
Contraindications
- Hypersensitivity to any component
- Concomitant use with nitrates
Side Effects
- Various body system related adverse effects
Pregnancy & Lactation
- Pregnancy category B
- Not indicated for use by women
- Animal studies showing no evidence of teratogenicity
Precautions & Warnings
- Caution when co-administered with alpha-blockers
- Considerations for different patient groups
- Potential for cardiac risk during sexual activity
- Sensitive patient groups
- Reported cases of prolonged erection and priapism
Overdose Effects
- Adverse events at high doses
- Standard supportive measures for overdose
Therapeutic Class
- Drugs for Erectile Dysfunction
Storage Conditions
- Dry place, away from light and heat
- Keep out of the reach of children