Novagra 25 mg (Tablet)

Unit Price: ৳ 20.26

Medicine Details

Category Details
Generic Sildenafil citrate
Company Novelta bestway pharma ltd

Indications

  • Treatment of erectile dysfunction in men
  • Treatment of pulmonary arterial hypertension

Description

Novagra is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).

Mechanism of Action

Increases levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood into the penile tissues

Pharmacokinetics

  • Absorption and Distribution: Rapidly absorbed with maximum plasma concentrations reached within 30 to 120 minutes
  • Metabolism and Excretion: Cleared by hepatic microsomal isoenzymes, excreted as metabolites predominantly in the feces

Dosage & Administration

  • Recommended Dose for Erectile Dysfunction:
    • 50 mg as needed, approximately 1 hour before sexual activity
    • Maximum recommended dose of 100 mg
    • Maximum recommended dosing frequency is once per day
  • Recommended Dose for Pulmonary Arterial Hypertension: 20 mg three times a day

Interactions

  • Metabolism Mediated by CYP Isoforms:
    • 3A4 (major route)
    • 2C9 (minor route)

Contraindications

  • Hypersensitivity to any component of this medication
  • Use with organic nitrates

Side Effects

  • Facial edema
  • Migraine
  • Anemia
  • Arthritis
  • Tremor
  • Dry eyes
  • Urinary frequency
  • Cardiac arrest

Pregnancy & Lactation

Pregnancy category B. Not indicated for use in women

Precautions & Warnings

  • Blood Pressure Effect: Caution when co-administered with alpha-blockers
  • Cardiac Risk: Not generally used in men for whom sexual activity is inadvisable due to underlying cardiovascular status
  • Sensitivity to Vasodilators:
    • Left ventricular outflow obstruction
    • Severely impaired autonomic control of blood pressure
  • Groups Requiring Caution:
    • Recent myocardial infarction, stroke, or life-threatening arrhythmia
    • Resting hypotension (BP <90/50) or hypertension (BP >170/110)
    • Cardiac failure or coronary artery disease causing unstable angina

Overdose Effects

Incidence rates and severities of adverse events increased with higher doses

Therapeutic Class

Drugs for Erectile Dysfunction

Storage Conditions

Keep in a dry place, away from light and heat, out of the reach of children

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