Novagra 25 mg (Tablet)
Unit Price: ৳ 20.26
Medicine Details
Category | Details |
---|---|
Generic | Sildenafil citrate |
Company | Novelta bestway pharma ltd |
Indications
- Treatment of erectile dysfunction in men
- Treatment of pulmonary arterial hypertension
Description
Novagra is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).
Mechanism of Action
Increases levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood into the penile tissues
Pharmacokinetics
- Absorption and Distribution: Rapidly absorbed with maximum plasma concentrations reached within 30 to 120 minutes
- Metabolism and Excretion: Cleared by hepatic microsomal isoenzymes, excreted as metabolites predominantly in the feces
Dosage & Administration
- Recommended Dose for Erectile Dysfunction:
- 50 mg as needed, approximately 1 hour before sexual activity
- Maximum recommended dose of 100 mg
- Maximum recommended dosing frequency is once per day
- Recommended Dose for Pulmonary Arterial Hypertension: 20 mg three times a day
Interactions
- Metabolism Mediated by CYP Isoforms:
- 3A4 (major route)
- 2C9 (minor route)
Contraindications
- Hypersensitivity to any component of this medication
- Use with organic nitrates
Side Effects
- Facial edema
- Migraine
- Anemia
- Arthritis
- Tremor
- Dry eyes
- Urinary frequency
- Cardiac arrest
Pregnancy & Lactation
Pregnancy category B. Not indicated for use in women
Precautions & Warnings
- Blood Pressure Effect: Caution when co-administered with alpha-blockers
- Cardiac Risk: Not generally used in men for whom sexual activity is inadvisable due to underlying cardiovascular status
- Sensitivity to Vasodilators:
- Left ventricular outflow obstruction
- Severely impaired autonomic control of blood pressure
- Groups Requiring Caution:
- Recent myocardial infarction, stroke, or life-threatening arrhythmia
- Resting hypotension (BP <90/50) or hypertension (BP >170/110)
- Cardiac failure or coronary artery disease causing unstable angina
Overdose Effects
Incidence rates and severities of adverse events increased with higher doses
Therapeutic Class
Drugs for Erectile Dysfunction
Storage Conditions
Keep in a dry place, away from light and heat, out of the reach of children