Silfil 50 mg (Tablet)

Unit Price: ৳ 30.10 (2 x 10: ৳ 602.00)

Strip Price: ৳ 301.00

Medicine Details

Category	Details
Generic	Sildenafil citrate
Company	Novatek pharmaceuticals ltd
Also available as	Silfil 100 mg tablet

Selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)

Inhibition of PDE5 by Silfil increases levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood into the penile tissues
Rapid absorption after oral administration with mean absolute bioavailability of 41%
Elimination predominantly by hepatic metabolism
Metabolized by cytochrome P450 3A4 and converted to an active metabolite with similar properties to the parent compound

Recommended dose for erectile dysfunction is 50 mg taken approximately 1 hour before sexual activity. Can be increased to a maximum of 100 mg or decreased to 25 mg based on effectiveness and toleration
Recommended dose for pulmonary arterial hypertension is 20 mg three times a day

Metabolism is mediated by the cytochrome P450 (CYP) isoforms 3A4 and 2C9, and inhibitors/inducers of these isoenzymes may affect Silfil clearance
Co-administration with CYP3A4 inhibitors may increase Silfil plasma levels
Co-administration with alpha-blockers should be done cautiously
Use with nitrates is contraindicated
Potential effects with other medications such as antihypertensives and protease inhibitors

Various body system-related side effects including cardiological, digestive, hemic and lymphatic, metabolic and nutritional, musculoskeletal, nervous, respiratory, dermatological, and urogenital effects
Serious cardiovascular, cerebrovascular, and vascular events reported post-marketing

Pregnancy category B with no adequate and well-controlled studies in pregnant women

Caution advised when co-administering with alpha-blockers
Considerations for patients with specific conditions such as cardiovascular disease, bleeding disorders, and anatomical deformation of the penis
Potential for cardiac risk of sexual activity in patients with preexisting cardiovascular disease
Sensitivity of vasodilators in patients with certain conditions
Warnings for prolonged erection and priapism, and precautions for patients taking ritonavir

Adverse events similar to those seen at lower doses but with increased incidence rates and severities
Standard supportive measures should be adopted in cases of overdose
Renal dialysis not expected to accelerate clearance as Silfil is highly bound to plasma proteins

Keep in a dry place, away from light and heat. Keep out of the reach of children