Indophyllin 100 mg (Tablet)
Unit Price: ৳ 0.42 (100's pack: ৳ 42.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Aminophylline |
| Company | Indo bangla pharmaceutical |
Indications
- Treatment of bronchospasm associated with asthma
- Treatment of emphysema
- Treatment of chronic bronchitis
- Treatment of cardiac asthma in adults
- Treatment of left ventricular or congestive cardiac failure in adults
Pharmacology
- Combination of theophylline and ethylenediamine
- Ethylenediamine increases the solubility of theophylline in water
- Theophylline relaxes bronchial smooth muscle
- Increases intracellular cAMP through inhibition of phosphodiesterase
- Adenosine receptor antagonism
- Prostaglandin antagonism
- Effects on intracellular calcium
Dosage
- Oral administration for chronic bronchospasm
- Initial adult dose of 225-450 mg twice daily
- Intravenous administration for acute severe bronchospasm
- Loading dose of 5 mg/kg (ideal body weight) or 250-500 mg by slow injection or infusion
- Maintenance infusion dose of 0.5 mg/kg/hr
- Max rate of 25 mg/min
Administration
- Tablets should be swallowed whole and not chewed
Contraindications
- Hypersensitivity to xanthines or ethylenediamine
- Active peptic ulcer
Side Effects
- Gastric irritation
- Nausea
- Vomiting
- Diarrhea
- Hematemesis
- Epigastric pain
- Tremor
- Ventricular arrhythmias
- Seizures
- Headache
- Irritability
- Restlessness
- Insomnia
- Twitching
- Convulsion
- Reflex hyperexcitability
- Palpitation
- Tachycardia
- Hypotension
- Circulatory failure
- Flushing
- Albuminuria
- Diuresis
- Hematuria
Pregnancy & Lactation
- Use should be balanced against the risk of uncontrolled disease
Precautions & Warnings
- Caution should be exercised in patients with peptic ulceration
- Caution should be exercised in patients with hyperthyroidism
- Caution should be exercised in patients with hypertension
- Caution should be exercised in patients with cardiac arrhythmias or other cardiovascular disease
- Caution should be exercised in patients with epilepsy
- Caution should be exercised in patients with heart failure
- Caution should be exercised in patients with hepatic dysfunction
- Caution should be exercised in patients with chronic alcoholism
- Caution should be exercised in patients with acute febrile illness
- Caution should be exercised in neonates
- Caution should be exercised in the elderly
Therapeutic Class
- Bronchodilator
- Methyl xanthine derivatives
- Respiratory stimulants: analeptics
- Theophylline & related drugs