Acmegra 25 mg (Tablet)
Unit Price: ৳ 18.00 (1 x 4: ৳ 72.00)
Strip Price: ৳ 72.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sildenafil citrate |
| Company | Acme laboratories ltd |
| Also available as |
Title
- Acmegra
Categories
- Phosphodiesterase Type 5 Inhibitor
- Erectile Dysfunction Medication
- Pulmonary Arterial Hypertension Treatment
Description
- Selective Inhibitor of cGMP-specific Phosphodiesterase Type 5 (PDE5)
- Requires Sexual Stimulation for Effectiveness
- Results in Smooth Muscle Relaxation and Inflow of Blood into Penile Tissues
Indications
- Treatment of Erectile Dysfunction in Men
- Treatment of Pulmonary Arterial Hypertension
Mechanism of Action
- Inhibition of PDE5
- Increase in cGMP levels
- Local Release of Nitric Oxide
- Smooth Muscle Relaxation
- Inflow of Blood into Penile Tissues
Pharmacokinetics
- Rapid Absorption After Oral Administration
- Mean Absolute Bioavailability of 41%
- Eliminated Predominantly by Hepatic Metabolism
- Terminal Half Lives of About 4 Hours
- Maximum Observed Plasma Concentrations Reached Within 30 to 120 Minutes
Dosage & Administration
- Recommended Starting Dose of 50 mg
- Can be Taken Anywhere from 4 Hours to 0.5 Hour Before Sexual Activity
- Maximum Recommended Dose of 100 mg
- Maximum Recommended Dosing Frequency is Once Per Day for Erectile Dysfunction
- Recommended Dose for Pulmonary Arterial Hypertension is 20 mg Three Times a Day
- Considerations for Increased Plasma Levels
Drug Interaction
- Metabolism Mediated by CYP Isoforms 3A4 and 2C9
- Inhibitors/Inducers May Affect Clearance
- Examples of Specific Inhibitors and their Effects
Contraindications
- Hypersensitivity to Any Component of the Medication
- Concomitant Use of Organic Nitrates
Side Effects
- Wide Range of Possible Adverse Effects on Different Body Systems
- Serious Cardiovascular, Cerebrovascular, and Vascular Events Reported Post-marketing
- Potential for Prolonged Erection, Priapism, and Hematuria
- Cardiac Risk of Sexual Activity in Patients with Preexisting Cardiovascular Disease
- Sudden Decrease or Loss of Hearing, Ocular and Urogenital Effects
Pregnancy & Lactation
- Pregnancy Category B
- No Adequate and Well-controlled Studies in Pregnant Women
Precautions & Warnings
- Underlying Causes of Erectile Dysfunction Should be Evaluated
- Caution with Co-administration of Alpha-blockers
- Considerations for Patients with Underlying Conditions
- Potential for Cardiac Risk of Sexual Activity
- Prolonged Erection and Priapism
- Caution with Ritonavir Co-administration
Overdose Effects
- Adverse Events Similar to Lower Doses but with Increased Incidence Rates and Severities
- Standard Supportive Measures Recommended
Therapeutic Class
- Drugs for Erectile Dysfunction
Storage Conditions
- Keep in a Dry Place, Away from Light and Heat
- Keep Out of the Reach of Children