Acmegra 100 mg (Tablet)
Unit Price: ৳ 45.00 (1 x 4: ৳ 180.00)
Strip Price: ৳ 180.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sildenafil citrate |
| Company | Acme laboratories ltd |
| Also available as |
Title and Categories
- Acmegra - Medicine Product
- Erectile Dysfunction Treatment
- Pulmonary Arterial Hypertension Medication
Dimensions
- N/A
Color Options
- N/A
Functions
- Treats men with erectile dysfunction
- Indicated in pulmonary arterial hypertension
Materials
- N/A
Technical Specifications
- Selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)
- Metabolized by cytochrome P450 isoforms 3A4 and 2C9
- Rapidly absorbed after oral administration with a mean absolute bioavailability of 41%
- Eliminated predominantly by hepatic metabolism
- Maximum observed plasma concentrations reached within 30 to 120 minutes of oral dosing in the fasted state
Design Elements
- N/A
Usability Features
- Requires sexual stimulation to be effective
- Recommended dosage starts at 50 mg and may be adjusted based on toleration
- Maximum recommended dosing frequency is once per day
Indications
- Treatment of men with erectile dysfunction
- Indicated in pulmonary arterial hypertension
Description
- Selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)
Mode of Action
- Causes smooth muscle relaxation and inflow of blood into the penile tissues
- Involves release of nitric oxide during sexual stimulation
- Enhances the effect of nitric oxide by inhibiting PDE5
- Rapidly absorbed after oral administration
- Cleared by hepatic microsomal isoenzymes
Dosage & Administration
- Recommended dose is 50 mg taken approximately 1 hour before sexual activity
- Dosage may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg based on toleration
- Maximum recommended dosing frequency is once per day
- Recommended dose for pulmonary arterial hypertension is 20 mg three times a day
Interaction
- Metabolism is primarily mediated by cytochrome P450 isoforms 3A4 and 2C9
- Inhibitors or inducers of these isoenzymes may affect Acmegra clearance
- Strong CYP3A4 inhibitors may have significant effects on Acmegra levels
Contraindications
- Hypersensitivity to any component of the medication
- Use of organic nitrates
Side Effects
- Various body system reactions including cardiovascular, digestive, musculoskeletal, nervous, respiratory, skin, and urogenital issues
- Serious cardiovascular, cerebrovascular, and vascular events have been reported post-marketing
Pregnancy & Lactation
- Pregnancy category B
- Not indicated for use by women
- Animal studies show no evidence of teratogenicity or embryotoxicity
Precautions & Warnings
- Evaluation of erectile dysfunction should include determination of potential underlying causes
- Caution advised when PDE5 inhibitors are co-administered with alpha-blockers
- Potential for cardiac risk of sexual activity in patients with preexisting cardiovascular disease
- Caution advised in patients with anatomical deformation of the penis or conditions predisposing to priapism
Overdose Effects
- Adverse events similar to lower doses but with increased incidence rates and severities
Therapeutic Class
- Drugs for Erectile Dysfunction
Storage Conditions
- Keep in a dry place, away from light and heat
- Keep out of the reach of children