Vegara 100 mg (Tablet)
Unit Price: ৳ 50.00 (1 x 4: ৳ 200.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sildenafil citrate |
| Company | Euro pharma ltd |
| Also available as |
Indications
- Treatment of erectile dysfunction
- Treatment of pulmonary arterial hypertension
- Requirement of sexual stimulation for effectiveness
Description
- Selective, reversible inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5)
- Increased levels of cyclic guanosine monophosphate (cGMP)
- Smooth muscle relaxation and inflow of blood into penile tissues
- No effect in the absence of sexual stimulation
Mechanism of Action
- Release of nitric oxide in the corpus cavernosum during sexual stimulation
- Activation of the enzyme guanylate cyclase
- Resulting increased cGMP levels leading to smooth muscle relaxation
Pharmacokinetics and Metabolism
- Mean absolute bioavailability of 41%
- Elimination predominantly by hepatic metabolism
- Terminal half-lives of about 4 hours
Absorption and Distribution
- Maximum observed plasma concentrations reached within 30-120 minutes
- Rate of absorption reduced when taken with a high fat meal
Metabolism and Excretion
- Cleared by hepatic microsomal isoenzymes
- Excreted as metabolites predominantly in the feces
Pharmacokinetics in Special Populations
- Elderly volunteers had reduced clearance of Sildenafil
Dosage & Administration
- Recommended starting dose of 50 mg
- Maximum recommended dose of 100 mg
- Recommended dosing frequency is once per day
- Dosage modification based on specific patient factors
Interaction
- Metabolism mediated by cytochrome P450 isoforms 3A4 and 2C9
- Effect of coadministration with inhibitors or inducers on clearance
Contraindications
- Hypersensitivity to any component of the medication
- Contraindicated in patients using organic nitrates
Side Effects
- Various side effects related to different body systems
Pregnancy & Lactation
- Pregnancy category B
- Not indicated for use by women
Precautions & Warnings
- Considerations for concomitant use with alpha-blockers
- Caution in patients with specific underlying conditions
- Potential cardiac risk of sexual activity in patients with preexisting cardiovascular disease
Overdose Effects
- Adverse events similar to lower doses but with increased incidence and severity
- Standard supportive measures should be adopted in cases of overdose
Therapeutic Class
- Drugs for Erectile Dysfunction
Storage Conditions
- Dry place, away from light and heat
- Keep out of the reach of children