Minomal R 350 mg (Retard Tablet)
Unit Price: ৳ 2.20 (5 x 10: ৳ 110.00)
Strip Price: ৳ 22.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Aminophylline |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Title
- Aminophylline Tablet
Categories
- Medicine
- Bronchodilator
- Respiratory Medication
Description
- A combination of theophylline and ethylenediamine for the treatment of bronchospasm associated with asthma, emphysema, chronic bronchitis, and cardiac asthma.
- Tablets should be swallowed whole and not chewed because of the structure of the tablet.
Dimensions
- 5mm x 10mm x 2mm
Color options
- White
Functions
- Relaxes bronchial smooth muscle
- Increases intracellular cAMP through inhibition of phosphodiesterase
- Adenosine receptor antagonism
- Prostaglandin antagonism
- Enhances intracellular calcium effects
Materials
- Theophylline
- Ethylenediamine
- Hydrated Lactose
- Microcrystalline Cellulose
- Sodium Starch Glycolate
Technical specifications
- Oral Dosage: Initially, 225-450 mg bid, increased if necessary
- Intravenous Dosage: Loading dose of 5 mg/kg with maintenance infusion dose of 0.5 mg/kg/hr
- Max rate for intravenous dosage: 25 mg/min
- Use with caution in patients with peptic ulceration, hyperthyroidism, hypertension, cardiac arrhythmias, or other cardiovascular diseases
Design elements
- Tablets should not be chewed due to structural composition
Usability features
- Should be given with caution to patients with hepatic dysfunction, chronic alcoholism, and acute febrile illness
- Use of aminophylline in pregnant women should be balanced against the risk of uncontrolled disease
Pharmacology
- Aminophylline is a combination of theophylline and ethylenediamine
- Ethylenediamine increases the solubility of theophylline in water
- Theophylline relaxes bronchial smooth muscle
- Suggested mechanisms include an increase in intracellular cAMP through inhibition of phosphodiesterase, adenosine receptor antagonism, prostaglandin antagonism, and effects on intracellular calcium
Indications
- Treatment and prophylaxis of bronchospasm associated with asthma, emphysema, and chronic bronchitis
- Treatment of cardiac asthma and left ventricular or congestive cardiac failure
Dosage information
- Oral Dosage: Initially, 225-450 mg bid, increased if necessary
- Intravenous Dosage: Loading dose of 5 mg/kg with maintenance infusion dose of 0.5 mg/kg/hr
- Max rate for intravenous dosage: 25 mg/min
Contraindications
- Hypersensitivity to xanthines or ethylenediamine
- Active peptic ulcer
Side effects
- Gastric irritation
- Nausea
- Vomiting
- Diarrhea
- Hematemesis
- Epigastric pain
- Tremor
- Ventricular arrhythmias
- Seizures
- Reactivation of peptic ulcer
- Headache
- Irritability
- Restlessness
- Insomnia
- Twitching
- Convulsion
- Reflex hyperexcitability
- Palpitation
- Tachycardia
- Hypotension
- Circulatory failure
- Flushing
- Albuminuria
- Diuresis
- Hematuria
- Inappropriate ADH syndrome
Pregnancy and lactation
- Use of aminophylline in pregnant women should be balanced against the risk of uncontrolled disease
Precautions and warnings
- Minomal R should be given with caution to patients with peptic ulceration, hyperthyroidism, hypertension, cardiac arrhythmias or other cardiovascular disease
- Should also be given with caution to patients with heart failure, hepatic dysfunction, chronic alcoholism, acute febrile illness, and to neonates and the elderly
Therapeutic class
- Bronchodilator
- Methyl xanthine derivatives
- Respiratory stimulants: analeptics
- Theophylline & related drugs