kTx 5 mg (Tablet)

Unit Price: ৳ 18.05 (5's pack: ৳ 90.26)

Medicine Details

Category Details
Generic Tadalafil
Company Kemiko pharmaceuticals ltd
Also available as
Ktx 10 mg tablet Ktx 20 mg tablet

Indications

  • Erectile Dysfunction (ED)
  • Benign Prostatic Hyperplasia (BPH)
  • Both Erectile Dysfunction and signs and symptoms of Benign Prostatic Hyperplasia

Pharmacology

Tadalafil is a selective phosphodiesterase type 5 (PDE5) inhibitor. Inhibition of PDE5 increases cGMP in smooth muscle cells. cGMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum, causing penile erection. PDE5 also is present in smooth muscles of the prostate and bladder wall. Inhibiting PDE5 increases cGMP concentrations leading to relaxation of smooth muscle in the prostate and bladder. Smooth muscle relaxation may improve blood flow to the urinary tract and widen the opening of the bladder neck, resulting in improved voiding.

Dosage & Administration

  • Erectile Dysfunction: For most patients the recommended starting dose is 10 mg. The dose may be increased to 20 mg or decreased to 5 mg based on requirement. The maximum dosing frequency is once daily. Tadalafil is effective for up to 36 hours.
  • Benign prostatic hyperplasia: The recommended dose is 5 mg taken at the same time every day.
  • Combined Erectile Dysfunction and Benign prostatic hyperplasia: The recommended dose is 5 mg at the same time every day.

Interaction

  • Nitrates (e.g., Isosorbide, Nitroglycerin)
  • Alpha adrenergic blockers
  • Antihypertensives
  • Alcohol
  • Antacids (magnesium hydroxide/aluminum hydroxide)
  • Ketoconazole
  • Ritonavir
  • Erythromycin
  • Itraconazole
  • Grapefruit juice
  • Other HIV protease inhibitors
  • Rifampin
  • Carbamazepine
  • Phenytoin & Phenobarbital

Contraindications

  • Use of Nitrates
  • Hypersensitivity reactions to Tadalafil

Side Effects

  • Headache
  • Dyspepsia
  • Back pain
  • Myalgia
  • Nasal pharyngitis
  • Nasal congestion
  • Change in Color Vision
  • Sudden vision loss
  • Hearing loss
  • Stevens-Johnson Syndrome
  • Exfoliative dermatitis
  • Angina
  • Stroke
  • Myocardial infarction
  • Severe hypotension
  • Tachycardia

Pregnancy & Lactation

Tadalafil has been assigned to pregnancy category B by the USFDA. Tadalafil is only recommended for use during pregnancy when benefit outweighs risk. There are no data on the excretion of Tadalafil in human milk. Caution should be used when administering tadalafil to nursing women.

Precautions & Warnings

  • Angina
  • Renal impairment
  • Hepatic impairment
  • Bleeding concomitant with Nitrates
  • Alpha Blockers
  • Alcohol
  • CYP3A4 Inhibitors (e.g., Ritonavir, Ketoconazole, Itraconazole)
  • Other PDE5 inhibitors

Therapeutic Class

Drugs for Erectile Dysfunction

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.

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