Megafil 10 mg (Tablet)

Unit Price: ৳ 35.11 (1 x 4: ৳ 140.44)
Strip Price: ৳ 140.44

Medicine Details

Category Details
Generic Tadalafil
Company Acme laboratories ltd
Also available as
Megafil 20 mg tablet

Indications

  • Erectile Dysfunction (ED)
  • Benign Prostatic Hyperplasia (BPH)
  • Both Erectile Dysfunction and signs and symptoms of Benign Prostatic Hyperplasia

Pharmacology

Tadalafil is a selective phosphodiesterase type 5 (PDE5) inhibitor. Inhibition of PDE5 increases cGMP in smooth muscle cells, causing smooth muscle relaxation and increased blood flow into the corpus cavernosum, leading to penile erection. It also relaxes smooth muscles in the prostate and bladder, improving blood flow to the urinary tract and widening the opening of the bladder neck, resulting in improved voiding.

Dosage & Administration

  • Erectile Dysfunction: Starting dose is 10 mg, may be increased to 20 mg or decreased to 5 mg. Maximum dosing frequency is once daily. Effective for up to 36 hours.
  • Benign prostatic hyperplasia: Recommended dose is 5 mg taken at the same time every day.
  • Combined Erectile Dysfunction and Benign prostatic hyperplasia: Recommended dose is 5 mg at the same time every day.

Interaction

May interact with Nitrates, Alpha adrenergic blockers, Antihypertensives, Alcohol, Antacids, Ketoconazole, Ritonavir, Erythromycin, Itraconazole, Grapefruit juice, other HIV protease inhibitors, Rifampin, Carbamazepine, Phenytoin & Phenobarbital.

Contraindications

  • Use of Nitrates (e.g., Nitroglycerine, Isosorbide) may increase hypotensive effects of Nitrates
  • Hypersensitivity reactions to Tadalafil

Side Effects

  • Headache
  • Dyspepsia
  • Back pain
  • Myalgia
  • Nasal pharyngitis
  • Nasal congestion
  • Change in Color Vision
  • Sudden vision loss
  • Hearing loss
  • Stevens-Johnson Syndrome
  • Exfoliative dermatitis
  • Angina
  • Stroke
  • Myocardial infarction
  • Severe hypotension
  • Tachycardia

Pregnancy & Lactation

Tadalafil has been assigned to pregnancy category B by the USFDA. Only recommended for use during pregnancy when benefit outweighs risk. Caution should be used when administering tadalafil to nursing women.

Precautions & Warnings

  • Angina
  • Renal impairment
  • Hepatic impairment
  • Bleeding concomitant with Nitrates
  • Alpha Blockers
  • Alcohol
  • CYP3A4 Inhibitors such as Ritonavir, Ketoconazole, Itraconazole
  • Other PDE5 inhibitors

Therapeutic Class

Drugs for Erectile Dysfunction

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.

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