Megafil 20 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Tadalafil |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Erectile Dysfunction (ED)
- Benign Prostatic Hyperplasia (BPH)
- Both Erectile Dysfunction and signs and symptoms of Benign Prostatic Hyperplasia
Pharmacology
Tadalafil is a selective phosphodiesterase type 5 (PDE5) inhibitor. Inhibition of PDE5 increases cGMP in smooth muscle cells. PDE5 is present in smooth muscles of the prostate and bladder wall. Inhibiting PDE5 increases cGMP concentrations leading to relaxation of smooth muscle in the prostate and bladder.
Dosage & Administration
- Erectile Dysfunction:
- Recommended starting dose: 10 mg
- Maximum dosing frequency: once daily
- Effective for up to 36 hours
- Benign prostatic hyperplasia: Recommended dose: 5 mg taken at the same time every day
- Combined Erectile Dysfunction and Benign prostatic hyperplasia: Recommended dose: 5 mg at the same time every day
Interaction
May interact with Nitrates, Alpha adrenergic blockers, Antihypertensives, Alcohol, Antacids, Ketoconazole, Ritonavir, Erythromycin, Itraconazole, Grapefruit juice, Rifampin, Carbamazepine, Phenytoin, Phenobarbital
Contraindications
- Use of Nitrates (e.g., Nitroglycerine, Isosorbide)
- Hypersensitivity reactions to Tadalafil
Side Effects
- Headache
- Dyspepsia
- Back pain
- Myalgia
- Nasal pharyngitis
- Nasal congestion
- Change in Color Vision
- Sudden vision loss
- Hearing loss
- Stevens-Johnson Syndrome
- Exfoliative dermatitis
- Angina
- Stroke
- Myocardial infarction
- Severe hypotension
- Tachycardia
Pregnancy & Lactation
Tadalafil has been assigned to pregnancy category B by the USFDA. Caution should be used when administering tadalafil to nursing women.
Precautions & Warnings
- Angina
- Renal impairment
- Hepatic impairment
- Bleeding concomitant with Nitrates
- Alpha Blockers
- Alcohol
- CYP3A4 Inhibitors
- Other PDE5 inhibitors
Therapeutic Class
Drugs for Erectile Dysfunction
Storage Conditions
Keep in a dry place, away from light and heat. Keep out of the reach of children.