G-Penicillin V 125 mg/5 ml (Powder for Suspension)

50 ml bottle: ৳ 20.00

Medicine Details

Category Details
Generic Phenoxymethyl penicillin penicillin v
Company Gonoshasthaya pharma ltd
Also available as
G penicillin v 250 mg tablet

Indications

  • Treatment of mild to moderately severe bacterial infections
  • Infections of the ear, nose and throat regions
  • Lower respiratory tract infections
  • Infections due to beta-hemolytic streptococci of group A
  • Skin infections
  • Lymphadenitis and lymphangitis of bacterial origin
  • Infections of the buccal cavity, gums or jaws
  • Prophylaxis of scarlet fever
  • Prophylaxis of infection after dental and oral surgical procedures
  • Prevent recurrences of rheumatic fever

Pharmacology

  • Phenoxymethyl penicillin is acid-stable
  • Best absorbed from the upper part of the small intestine
  • Convenient means of treating Grampositive infections
  • Advantage over penicillin G in resistance to inactivation by gastric acid

Dosage

  • Dosage determined according to sensitivity of the causative micro-organism and the severity of the infection
  • Adult dosage: 250-500 mg 6 hourly
  • Children dosage: 125-250 mg 6 hourly
  • Infants dosage: 62.5-125 mg 6 hourly

Administration

  • Best taken on an empty stomach, preferably one hour before meals
  • Tablets are swallowed without chewing with sufficient amounts of liquid
  • Syrup requires shaking vigorously before each use

Interaction

  • Concurrent intake of food reduces the rate of absorption
  • Concomitant administration of penicillins may affect methotrexate levels
  • Disturbed absorption of other orally administered drugs if diarrhoea occurs
  • Concurrent use with bacteriostatic chemotherapeutics or antibiotics may attenuate or abolish penicillin activity
  • Interference with oral contraceptives is uncertain
  • Intestinal sterilization with aminoglycosides may reduce absorption
  • Combined use with oral anticoagulants may prolong prothrombin time/INR
  • Interference with certain laboratory and diagnostic tests

Contraindications

  • Must not be administered in patients with hypersensitivity to penicillins or any of the excipients
  • Must not be used to treat patients with severe gastrointestinal disorders accompanied by vomiting and diarrhea

Side Effects

  • Hypersensitivity reactions involving the skin
  • Allergic reactions such as drug fever, vasculitis, serum sickness or interstitial nephritis
  • Anaphylactic or anaphylactoid reactions
  • Skin rashes or inflammation of mucous membranes
  • Gastrointestinal disturbances
  • Diarrhoea, enterocolitis, pseudomembranous colitis
  • Changes in blood picture
  • Herxheimer's reaction, drug-induced aseptic meningitis
  • Transient discolouration of the teeth

Pregnancy & Lactation

  • Crosses the placenta
  • May be used at any time throughout pregnancy
  • Passes into breast milk in small amounts
  • May be used during lactation with potential effects on the infant

Precautions & Warnings

  • Consider cross-allergy between cephalosporins and penicillins
  • Consider potassium content when treating patients with heart diseases or electrolyte disturbances
  • Predisposes the patient to encephalopathy risk
  • May lead to the proliferation of resistant micro-organisms
  • No indication of impaired ability to drive or operate machinery

Overdose Effects

  • Low toxicity with broad therapeutic range
  • Risk of encephalopathy in cases of administration of beta-lactam antibiotics
  • Elimination can be accomplished through haemodialysis

Therapeutic Class

  • Benzylpenicillin & Phenoxymethyl penicillin

Storage Conditions

  • Store in a cool and dry place
  • Protect from light

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