Open 500 mg (Tablet)
Unit Price: ৳ 5.50 (10 x 10: ৳ 550.00)
Strip Price: ৳ 55.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Phenoxymethyl penicillin penicillin v |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Treatment of mild to moderately severe bacterial infections
- Infections of ear, nose, and throat regions
- Infections of lower respiratory tract
- Infections due to beta-hemolytic streptococci
- Skin infections
- Lymphadenitis and lymphangitis
- Infections of buccal cavity, gums, or jaws
- Prophylaxis of scarlet fever
- Prevention of recurrences of rheumatic fever
- Prophylaxis of infection after dental and oral surgical procedures
- Combination therapy with other antibiotics
Pharmacology
- Absorbed from upper part of small intestine
- Best absorbed in potassium salt form
- Convenient for treating Gram-positive infections
- Resistant to inactivation by gastric acid
Dosage
- Dosage based on sensitivity of micro-organism and severity of infection
- Adult dosage: 250-500 mg every 6 hours
- Children dosage: varies based on age
- Infants dosage: varies based on age
- Best taken on empty stomach
Administration
- Best taken on empty stomach
- Tablets swallowed whole with liquid
- Syrup to be shaken vigorously before use
Interaction
- Reduced absorption rate when taken with food
- Potential drug interactions with methotrexate, probenecid, etc.
- Inhibition of penicillin renal excretion with probenecid
- Effects on oral contraceptives and anticoagulants
- False-positive results in urine glucose tests
Contraindications
- Hypersensitivity to penicillins or excipients
- Severe gastrointestinal disorders with vomiting and diarrhea
Side Effects
- Hypersensitivity reactions
- Allergic reactions
- Skin reactions
- Anaphylactic reactions
- Gastrointestinal disturbances
- Diarrhoea and enterocolitis
- Blood abnormalities
- Herxheimer's reaction
- Aseptic meningitis
- Teeth discolouration
- Proliferation of resistant microorganisms
Pregnancy & Lactation
- Crosses placenta
- Safe for use during pregnancy
- Passes into breast milk in small amounts
- May cause diarrhoea and yeast colonization in infants
Precautions & Warnings
- Consider cross-allergy with cephalosporins
- Check potassium content for patients with heart diseases
- Encephalopathy risk in case of overdose or renal impairment
- Monitor for resistance development
- Consider sugar content for diabetic patients
- No impairment of ability to drive or operate machinery
Overdose Effects
- Low toxicity and broad therapeutic range
- Risk of encephalopathy with overdose
- Elimination through hemodialysis
Therapeutic Class
- Benzylpenicillin & Phenoxymethyl penicillin
Storage Conditions
- Store in cool and dry place
- Protect from light