Open 125 mg/5 ml (Powder for Suspension)
50 ml bottle: ৳ 35.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Phenoxymethyl penicillin penicillin v |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Treatment of mild to moderately severe bacterial infections
- Infections of ear, nose, and throat regions
- Infections of lower respiratory tract
- Infections due to beta-hemolytic streptococci
- Skin infections
- Lymphadenitis and lymphangitis
- Prophylaxis of scarlet fever
- Prevention of recurrences of rheumatic fever
- Prophylaxis of infection after dental procedures
- Combination therapy with other antibiotics
Pharmacology
- Acid-stable and absorbed from upper small intestine
- Potassium salt best absorbed
- Convenient for treating Gram-positive infections
- Advantage over penicillin G in resistance to gastric acid inactivation
Dosage
- Determined according to sensitivity of causative micro-organism
- Adjustable based on severity of infection and clinical response
- Adult dosage: 250-500 mg every 6 hours
- Children's dosage: varies by age and weight
- Best taken with an empty stomach
Administration
- Best taken on an empty stomach
- Tablets swallowed without chewing
- Syrup shaken vigorously before use
Interaction
- Reduced absorption rate with concurrent food intake
- Potential drug interactions with methotrexate, probenecid, and others
- Interference with laboratory and diagnostic tests
Contraindications
- Hypersensitivity to penicillins
- Severe gastrointestinal disorders with vomiting and diarrhea
Side Effects
- Hypersensitivity reactions
- Skin rashes and inflammation of mucous membranes
- Gastrointestinal disturbances
- Enterocolitis and pseudomembranous colitis
- Blood picture changes
- Herxheimer's reaction
- Drug-induced aseptic meningitis
- Transient teeth discoloration
- Proliferation of resistant microorganisms
- Encephalopathy risk
Pregnancy & Lactation
- Crosses the placenta
- Passes into breast milk in small amounts
- Use in pregnancy with appropriate indication
- Possibility of diarrhoea and yeast colonization in the infant during lactation
Precautions & Warnings
- Consideration of cross-allergy with cephalosporins
- Consideration of potassium content in heart disease patients
- Encephalopathy risk in case of overdose or renal impairment
- Regular check of patient's condition for proliferation of resistant microorganisms
- Consideration of sugar content in patients with diabetes mellitus
- No impaired ability to drive or operate machinery
- Caution in case of adverse reactions
Overdose Effects
- Low toxicity with broad therapeutic range
- Risk of encephalopathy in case of beta-lactam antibiotic administration
- No special measures required in event of overdosage
- Elimination possible through haemodialysis
Therapeutic Class
- Benzylpenicillin & Phenoxymethyl penicillin
Storage Conditions
- Store in a cool and dry place
- Protect from light