Open 125 mg/5 ml (Powder for Suspension)

50 ml bottle: ৳ 35.00

Medicine Details

Category Details
Generic Phenoxymethyl penicillin penicillin v
Company Opsonin pharma ltd
Also available as
Open 250 mg tablet Open 500 mg tablet

Indications

  • Treatment of mild to moderately severe bacterial infections
  • Infections of ear, nose, and throat regions
  • Infections of lower respiratory tract
  • Infections due to beta-hemolytic streptococci
  • Skin infections
  • Lymphadenitis and lymphangitis
  • Prophylaxis of scarlet fever
  • Prevention of recurrences of rheumatic fever
  • Prophylaxis of infection after dental procedures
  • Combination therapy with other antibiotics

Pharmacology

  • Acid-stable and absorbed from upper small intestine
  • Potassium salt best absorbed
  • Convenient for treating Gram-positive infections
  • Advantage over penicillin G in resistance to gastric acid inactivation

Dosage

  • Determined according to sensitivity of causative micro-organism
  • Adjustable based on severity of infection and clinical response
  • Adult dosage: 250-500 mg every 6 hours
  • Children's dosage: varies by age and weight
  • Best taken with an empty stomach

Administration

  • Best taken on an empty stomach
  • Tablets swallowed without chewing
  • Syrup shaken vigorously before use

Interaction

  • Reduced absorption rate with concurrent food intake
  • Potential drug interactions with methotrexate, probenecid, and others
  • Interference with laboratory and diagnostic tests

Contraindications

  • Hypersensitivity to penicillins
  • Severe gastrointestinal disorders with vomiting and diarrhea

Side Effects

  • Hypersensitivity reactions
  • Skin rashes and inflammation of mucous membranes
  • Gastrointestinal disturbances
  • Enterocolitis and pseudomembranous colitis
  • Blood picture changes
  • Herxheimer's reaction
  • Drug-induced aseptic meningitis
  • Transient teeth discoloration
  • Proliferation of resistant microorganisms
  • Encephalopathy risk

Pregnancy & Lactation

  • Crosses the placenta
  • Passes into breast milk in small amounts
  • Use in pregnancy with appropriate indication
  • Possibility of diarrhoea and yeast colonization in the infant during lactation

Precautions & Warnings

  • Consideration of cross-allergy with cephalosporins
  • Consideration of potassium content in heart disease patients
  • Encephalopathy risk in case of overdose or renal impairment
  • Regular check of patient's condition for proliferation of resistant microorganisms
  • Consideration of sugar content in patients with diabetes mellitus
  • No impaired ability to drive or operate machinery
  • Caution in case of adverse reactions

Overdose Effects

  • Low toxicity with broad therapeutic range
  • Risk of encephalopathy in case of beta-lactam antibiotic administration
  • No special measures required in event of overdosage
  • Elimination possible through haemodialysis

Therapeutic Class

  • Benzylpenicillin & Phenoxymethyl penicillin

Storage Conditions

  • Store in a cool and dry place
  • Protect from light

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