Pacin-V 250 mg (Tablet)
Unit Price: ৳ 2.80 (10 x 10: ৳ 280.00)
Strip Price: ৳ 28.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Phenoxymethyl penicillin penicillin v |
| Company | Zenith pharmaceuticals ltd |
Indications
- Treatment of mild to moderately severe bacterial infections
- Infections of ear, nose, and throat regions
- Infections of lower respiratory tract
- Skin infections
- Prophylaxis of scarlet fever
- Prevention of recurrences of rheumatic fever
- Prophylaxis of infection after dental and oral surgical procedures
Pharmacology
- Phenoxymethyl penicillin is acid-stable
- Best absorbed from upper part of small intestine
- Convenient for treating Gram-positive infections
- Resistant to inactivation by gastric acid
Dosage
- Dosage determined by sensitivity of causative micro-organism
- Dosage adjustment based on clinical response
- Adult dosage: 250-500 mg 6 hourly
- Children dosage: 125-250 mg 6 hourly
- Infants dosage: 62.5-125 mg 6 hourly
Administration
- Best taken on empty stomach
- Tablets swallowed without chewing
- Syrup bottle must be shaken vigorously before use
Interaction
- Food interactions affecting absorption rate
- Drug interactions with methotrexate, probenecid, indomethacin, etc.
- Impact on oral contraceptives effectiveness
- Influence on laboratory and diagnostic tests
Contraindications
- Hypersensitivity to penicillins
- Severe gastrointestinal disorders with vomiting and diarrhea
Side Effects
- Hypersensitivity reactions
- Allergic reactions like drug fever, vasculitis
- Skin rashes and mucous membrane inflammation
- Gastrointestinal disturbances
- Enterocolitis and pseudomembranous colitis
- Blood picture changes like leucopenia
- Encephalopathy risks
Pregnancy & Lactation
- Crosses placenta and into breast milk
- Use throughout pregnancy with appropriate indication
- Small amounts in breast milk may cause diarrhoea and yeast colonization in infant
Precautions & Warnings
- Cross-allergy with cephalosporins
- Consider potassium content in heart patients
- Monitoring for resistant microorganisms proliferation
- Sugar content consideration in diabetic patients
- Encephalopathy risks, caution while driving or operating machinery
Overdose Effects
- Low toxicity with broad therapeutic range
- Risk of encephalopathy in beta-lactam antibiotic overdose
- No acute toxicity with single oral multiple therapeutic dose
- Elimination through haemodialysis
Therapeutic Class
- Benzylpenicillin & Phenoxymethyl penicillin
Storage Conditions
- Store in cool, dry place
- Protect from light