Penicillin 250 mg (Tablet)
Unit Price: ৳ 2.28 (100's pack: ৳ 228.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Phenoxymethyl penicillin penicillin v |
| Company | Bristol pharmaceuticals ltd |
Indications
- Treatment of mild to moderately severe bacterial infections
- Infections of the ear, nose, and throat regions
- Infections of the lower respiratory tract
- Infections due to beta-hemolytic streptococci
- Skin infections
- Lymphadenitis and lymphangitis
- Prophylaxis of scarlet fever
- Prevention of recurrences of rheumatic fever
- Prophylaxis of infection after dental and oral surgical procedures
- Combination therapy with other appropriate antibiotics
Pharmacology
- Acid-stable and absorbed from the upper part of the small intestine
- Best absorbed as potassium salt
- Convenient for treating Gram-positive infections
- Advantage over penicillin G in resistance to gastric acid inactivation
Dosage
- Dosage determination based on sensitivity of causative micro-organism and severity of infection
- Adult dosage: 250-500 mg 6 hourly
- Children dosage: 125-250 mg 6 hourly
- Infants dosage: 62.5-125 mg 6 hourly
- Best taken with an empty stomach
Administration
- Best taken on an empty stomach
- Tablets swallowed without chewing with sufficient liquid
- Syrup to be shaken vigorously before use
Interaction
- Concurrent intake of food reduces rate of absorption
- Potential drug interactions with methotrexate, bacteriostatic chemotherapeutics, probenecid, indomethacin, oral contraceptives, aminoglycosides, oral anticoagulants
- Interference with laboratory and diagnostic tests
Contraindications
- Hypersensitivity to penicillins or any excipients
- Severe gastrointestinal disorders accompanied by vomiting and diarrhea
Side Effects
- Hypersensitivity reactions involving the skin
- Allergic reactions such as drug fever, vasculitis, interstitial nephritis
- Anaphylactic or anaphylactoid reactions
- Skin rashes or inflammation of mucous membranes
- Gastrointestinal disturbances
- Diarrhoea as a symptom of enterocolitis
- Changes in blood picture
- Herxheimer's reaction
- Transient discolouration of teeth
- Proliferation of resistant microorganisms
- Encephalopathy risk
Pregnancy & Lactation
- Crosses the placenta
- Passes into breast milk in small amounts
- Use during pregnancy with appropriate indication
- Use during lactation with potential side effects in infant
Precautions & Warnings
- Possibility of cross-allergy with cephalosporins
- Consideration of potassium content in patients with heart diseases
- Regular intervals checking of patient's condition
- Conducting appropriate measures in case of secondary infection
- Consideration of sugar content in patients with diabetes mellitus
- No indication of impaired ability to drive or operate machinery
- Encephalopathy risk precautions
Overdose Effects
- Low toxicity with broad therapeutic range
- Risk of encephalopathy with beta-lactam antibiotics
- Elimination via haemodialysis
Therapeutic Class
- Benzylpenicillin & Phenoxymethyl penicillin
Storage Conditions
- Store in cool and dry place
- Protect from light