Penvik Forte 250 mg/5 ml (Powder for Suspension)
100 ml bottle: ৳ 84.43
Medicine Details
| Category | Details |
|---|---|
| Generic | Phenoxymethyl penicillin penicillin v |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Mild to moderately severe bacterial infections treatment
- Infections of the ear, nose and throat regions
- Infections of the lower respiratory tract
- Infections due to beta-hemolytic streptococci of group A
- Skin infections treatment
- Lymphadenitis and lymphangitis treatment
- Infections of the buccal cavity, gums or jaws treatment
- Prophylaxis of scarlet fever
- Prevention of recurrences of rheumatic fever
- Prophylaxis of infection after dental and oral surgical procedures
Pharmacology
- Acid-stable drug absorption
- Best absorbed potassium salt of Phenoxymethyl penicillin
- Convenient means of treating Gram-positive infections
- Advantage over penicillin G in resistance to inactivation by gastric acid
Dosage
- Dosage determination based on sensitivity of causative micro-organism and severity of infection
- Dosage adjustment according to clinical response
- Adult dosage: 250-500 mg 6 hourly
- Children dosage: 125-250 mg 6 hourly
- Infants dosage: 62.5-125 mg 6 hourly
Administration
- Best taken on an empty stomach
- Tablets to be swallowed without chewing with liquid
- Shaking vigorously required before syrup use
Interaction
- Reduction in the rate of absorption with concurrent food intake
- Potential drug interactions with methotrexate, bacteriostatic chemotherapeutics, probenecid, indomethacin, phenylbutazone, salicylates, sulfinpyrazone, oral contraceptives, aminoglycosides, oral anticoagulants
- Interference with laboratory and diagnostic tests
Contraindications
- Hypersensitivity to penicillins or any excipients
- Severe gastrointestinal disorders with vomiting and diarrhea
Side Effects
- Hypersensitivity reactions involving the skin
- Allergic reactions including anaphylactic or anaphylactoid reactions
- Skin rashes or inflammation of mucous membranes
- Gastrointestinal disturbances
- Diarrhoea and enterocolitis
- Changes in blood picture
- Herxheimer's reaction
- Aseptic meningitis
- Transient discolouration of the teeth
- Encephalopathy risk
Pregnancy & Lactation
- Crosses the placenta
- Passes into breast milk in small amounts
- Safe use during pregnancy and lactation, with potential infant effects
Precautions & Warnings
- Cross-allergy between cephalosporins and penicillins
- Consideration of potassium content in patients with heart diseases or serious electrolyte disturbances
- Proliferation of resistant micro-organisms
- Regular patient condition checks and secondary infection management
- Consideration of sugar content in patients with diabetes mellitus
- No impaired ability to drive or operate machinery
- Encephalopathy risk
Overdose Effects
- Low toxicity with broad therapeutic range
- Risk of encephalopathy with beta-lactam antibiotics
- Elimination through haemodialysis
Therapeutic Class
- Benzylpenicillin & Phenoxymethyl penicillin
Storage Conditions
- Store in a cool and dry place, protect from light