Penvik Forte 250 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 84.43

Medicine Details

Category Details
Generic Phenoxymethyl penicillin penicillin v
Company Square pharmaceuticals plc
Also available as
Penvik 250 mg tablet Penvik ds 500 mg tablet

Indications

  • Mild to moderately severe bacterial infections treatment
  • Infections of the ear, nose and throat regions
  • Infections of the lower respiratory tract
  • Infections due to beta-hemolytic streptococci of group A
  • Skin infections treatment
  • Lymphadenitis and lymphangitis treatment
  • Infections of the buccal cavity, gums or jaws treatment
  • Prophylaxis of scarlet fever
  • Prevention of recurrences of rheumatic fever
  • Prophylaxis of infection after dental and oral surgical procedures

Pharmacology

  • Acid-stable drug absorption
  • Best absorbed potassium salt of Phenoxymethyl penicillin
  • Convenient means of treating Gram-positive infections
  • Advantage over penicillin G in resistance to inactivation by gastric acid

Dosage

  • Dosage determination based on sensitivity of causative micro-organism and severity of infection
  • Dosage adjustment according to clinical response
  • Adult dosage: 250-500 mg 6 hourly
  • Children dosage: 125-250 mg 6 hourly
  • Infants dosage: 62.5-125 mg 6 hourly

Administration

  • Best taken on an empty stomach
  • Tablets to be swallowed without chewing with liquid
  • Shaking vigorously required before syrup use

Interaction

  • Reduction in the rate of absorption with concurrent food intake
  • Potential drug interactions with methotrexate, bacteriostatic chemotherapeutics, probenecid, indomethacin, phenylbutazone, salicylates, sulfinpyrazone, oral contraceptives, aminoglycosides, oral anticoagulants
  • Interference with laboratory and diagnostic tests

Contraindications

  • Hypersensitivity to penicillins or any excipients
  • Severe gastrointestinal disorders with vomiting and diarrhea

Side Effects

  • Hypersensitivity reactions involving the skin
  • Allergic reactions including anaphylactic or anaphylactoid reactions
  • Skin rashes or inflammation of mucous membranes
  • Gastrointestinal disturbances
  • Diarrhoea and enterocolitis
  • Changes in blood picture
  • Herxheimer's reaction
  • Aseptic meningitis
  • Transient discolouration of the teeth
  • Encephalopathy risk

Pregnancy & Lactation

  • Crosses the placenta
  • Passes into breast milk in small amounts
  • Safe use during pregnancy and lactation, with potential infant effects

Precautions & Warnings

  • Cross-allergy between cephalosporins and penicillins
  • Consideration of potassium content in patients with heart diseases or serious electrolyte disturbances
  • Proliferation of resistant micro-organisms
  • Regular patient condition checks and secondary infection management
  • Consideration of sugar content in patients with diabetes mellitus
  • No impaired ability to drive or operate machinery
  • Encephalopathy risk

Overdose Effects

  • Low toxicity with broad therapeutic range
  • Risk of encephalopathy with beta-lactam antibiotics
  • Elimination through haemodialysis

Therapeutic Class

  • Benzylpenicillin & Phenoxymethyl penicillin

Storage Conditions

  • Store in a cool and dry place, protect from light

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