Pharmapen 250 mg (Tablet)
Unit Price: ৳ 2.20 (100's pack: ৳ 220.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Phenoxymethyl penicillin penicillin v |
| Company | Pharmadesh laboratories ltd |
| Also available as |
Indications
- Treatment of bacterial infections in ear, nose, and throat regions
- Treatment of infections in lower respiratory tract
- Treatment of infections due to beta-hemolytic streptococci of group A
- Treatment of skin infections
- Prophylaxis of scarlet fever
- Prophylaxis of infection after dental and oral surgical procedures
- Combination therapy with other appropriate antibiotics
Pharmacology
- Absorption from upper part of small intestine
- Best absorption with potassium salt form
- Administration with meals
- Resistance to inactivation by gastric acid
Dosage
- Adult dosage: 250-500 mg 6 hourly
- Children dosage: 125-250 mg 6 hourly
- Infants dosage: 62.5-125 mg 6 hourly
Administration
- Best taken on an empty stomach
- Tablets swallowed without chewing
- Syrup shaken vigorously before use
Interaction
- Reduction in rate of absorption with concurrent food intake
- Potential drug interactions with methotrexate, bacteriostatic chemotherapeutics, probenecid, oral anticoagulants, and more
- Interference with laboratory and diagnostic tests
Contraindications
- Hypersensitivity to penicillins or any of the excipients
- Severe gastrointestinal disorders accompanied by vomiting and diarrhea
Side Effects
- Hypersensitivity reactions involving the skin
- Allergic reactions like drug fever, vasculitis, or interstitial nephritis
- Anaphylactic or anaphylactoid reactions
- Skin rashes or inflammation of mucous membranes
- Gastrointestinal disturbances
- Haemorrhagic enterocolitis
- Reduction in blood cell counts
- Herxheimer's reaction
- Transient discolouration of the teeth
- Proliferation of resistant microorganisms
Pregnancy & Lactation
- Crosses the placenta
- Passes into breast milk in small amounts
- May be used during pregnancy and lactation
Precautions & Warnings
- Cross-allergy between cephalosporins and penicillins
- Consideration of potassium content in patients with heart diseases or serious electrolyte disturbances
- Risk of encephalopathy, particularly in case of overdose or renal impairment
- Checking the patient's condition at regular intervals
- Consideration of sugar content in patients with diabetes mellitus
Overdose Effects
- Low toxicity with broad therapeutic range
- Risk of encephalopathy, particularly in case of overdose or renal impairment
- Elimination through haemodialysis
Therapeutic Class
- Benzylpenicillin & Phenoxymethyl penicillin
Storage Conditions
- Store in a cool and dry place
- Protect from light