Phenoxymethyl 250 mg (Tablet)
Unit Price: ৳ 1.50 (100's pack: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Phenoxymethyl penicillin penicillin v |
| Company | Apc pharma ltd |
Indications
- Treatment of mild to moderately severe bacterial infections
- Infections of ear, nose, and throat regions
- Infections of lower respiratory tract
- Infections due to beta-hemolytic streptococci
- Skin infections
- Lymphadenitis and lymphangitis
- Prophylaxis of scarlet fever
- Prevention of recurrences of rheumatic fever
- Prophylaxis of infection after dental and oral surgical procedures
- Combination with another appropriate antibiotic
Pharmacology
- Phenoxymethyl penicillin is acid-stable
- Best absorbed in potassium salt form
- Convenient treatment of Gram-positive infections
- Advantage over penicillin G in resistance to gastric acid inactivation
Dosage
- Dosage should be determined based on sensitivity of causative micro-organism and severity of infection
- Adult dosage: 250-500 mg 6 hourly
- Children dosage: 125-250 mg 6 hourly
- Best taken with an empty stomach
Administration
- Best taken on an empty stomach
- Tablets should be swallowed without chewing with sufficient liquid
- Syrup bottle needs to be shaken vigorously before use
Interaction
- Concurrent intake of food reduces absorption rate
- Concomitant administration may increase levels of methotrexate
- Diarrhoea may disturb absorption of other orally administered drugs
- Concurrent use with bacteriostatic chemotherapeutics or antibiotics may attenuate or abolish activity of penicillins
- Concurrent administration of probenecid inhibits renal excretion of penicillins
Contraindications
- Hypersensitivity to penicillins or any excipients
- Severe gastrointestinal disorders with vomiting and diarrhea
Side Effects
- Hypersensitivity reactions involving the skin
- Serious allergic reactions
- Anaphylactic or anaphylactoid reactions
- Skin rashes and inflammation of mucous membranes
- Gastrointestinal disturbances
- Diarrhoea as a symptom of enterocolitis
- Changes in blood picture
- Herxheimer's reaction
- Transient discolouration of the teeth
- Proliferation of resistant microorganisms
Pregnancy & Lactation
- Crosses the placenta
- May be used throughout pregnancy with appropriate indication
- Passes into breast milk in small amounts
- May be used during lactation with potential for diarrhoea and yeast colonization in infant
Precautions & Warnings
- Consider possibility of cross-allergy between cephalosporins and penicillins
- Consider potassium content in patients with heart diseases or serious electrolyte disturbances
- Check patient's condition at regular intervals for proliferation of resistant micro-organisms
- Consider sugar content in patients with diabetes mellitus
- No indication of impaired ability to drive or operate machinery
Overdose Effects
- Low toxicity with broad therapeutic range
- Risk of encephalopathy in cases of administration of beta-lactam antibiotics
- No special measures required other than discontinuation of medication
- Elimination can be accomplished through haemodialysis
Therapeutic Class
- Benzylpenicillin
- Phenoxymethyl penicillin
Storage Conditions
- Store in a cool and dry place
- Protect from light