Pacet 100 mg (Tablet)

Unit Price: ৳ 5.03 (3 x 10: ৳ 150.88)
Strip Price: ৳ 50.29

Medicine Details

Category Details
Generic Amiodarone hydrochloride
Company Beximco pharmaceuticals ltd
Also available as
Pacet 200 mg tablet

Product Title

  • Pacet Tablet
  • Pacet Injection

Categories

  • Antiarrhythmic Medication
  • Pharmacological Agent
  • Heart Rhythm Corrector
  • Potassium Channel Blocker

Dosage Form

  • Tablet
  • Injection

Dosage Strength

  • 200mg
  • 1000mg

Dosage Schedule

  • 3 times daily for 1 week then reduced to 200mg twice daily
  • Initial Load: 150mg per 100mL infused over 10 minutes, followed by 1mg/min for 6 hours, followed by 0.5mg/min thereafter

Indications

  • Treatment of ventricular fibrillation
  • Prophylaxis of ventricular tachycardia
  • Correction of abnormal heart rhythms
  • Management of atrial fibrillation and atrial flutter

Pharmacological Actions

  • Delay in heart's electrical system recharge
  • Prolongation of electrical phase during heart's muscle cell stimulation
  • Slowing of electrical conduction through the heart
  • Reduction in rapidity of firing of the heart's pacemaker
  • Dilation of blood vessels

Interaction with

  • B blockers (Atenolol, Propranolol, Metoprolol)
  • Calcium channel blockers (Verapamil, Diltiazem)
  • Digoxin
  • Flecainide
  • Procainamide
  • Quinidine
  • Tricyclic antidepressants (TCA)
  • Warfarin
  • Dextromethorphan

Contraindications

  • Cardiogenic shock
  • Severe sinus-node dysfunction
  • Second- or third-degree atrioventricular block
  • Episode-induced syncope with bradycardia
  • Hypersensitivity to the drug or its components

Side Effects

  • Lung-related reactions
  • Fatal liver toxicity
  • Reversible corneal microdeposits
  • Impaired vision due to optic neuritis
  • Peripheral neuropathy and myopathy
  • Bradycardia and conduction disturbances
  • Phototoxicity
  • Persistent skin discoloration
  • Hypothyroidism
  • Hyperthyroidism
  • Raised serum transaminases
  • Jaundice
  • Hepatitis
  • Cirrhosis
  • Nausea
  • Vomiting
  • Metallic taste
  • Tremor
  • Sweating
  • Vertigo
  • Headache
  • Sleeplessness
  • Fatigue
  • Alopecia
  • Raised intracranial pressure
  • Ataxia
  • Rashes
  • Vasculitis
  • Renal involvement
  • Thrombocytopenia
  • Haemolytic or aplastic anemia

Pregnancy & Lactation

  • Not recommended during pregnancy
  • Potential risk to the fetus
  • Safe use during lactation not established

Therapeutic Class

  • Potassium Channel Blockers

Storage Conditions

  • Keep below 30°C temperature
  • Keep away from light & moisture
  • Keep out of the reach of children

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