Penci-V 250 mg (Tablet)
Unit Price: ৳ 1.53 (100's pack: ৳ 153.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Phenoxymethyl penicillin penicillin v |
| Company | Skylab pharmaceuticals ltd |
| Also available as |
Indications
- Mild to moderately severe bacterial infections
- Penicillin susceptible pathogens
- Ear, nose, and throat infections
- Lower respiratory tract infections
- Skin infections
- Prophylaxis of scarlet fever
- Prophylaxis of infection after dental procedures
- Combination therapy with other antibiotics
- Prevention of recurrences of rheumatic fever
Pharmacology
- Acid-stable
- Absorbed from the upper part of the small intestine
- Best absorbed in potassium salt form
- Convenient for treating Gram-positive infections
- Resistant to inactivation by gastric acid
Dosage
- Determined according to sensitivity of micro-organism
- Adjusted to clinical response
- Adult dosage: 250-500 mg 6 hourly
- Children dosage: 125-250 mg 6 hourly
- Infants dosage: 62.5-125 mg 6 hourly
- Best taken with empty stomach
Administration
- Best taken on an empty stomach
- Tablets swallowed without chewing
- Syrup shaken vigorously before use
Interaction
- Concurrent intake of food reduces rate of absorption
- Possible drug interactions with methotrexate, bacteriostatic antibiotics, probenecid, indomethacin, oral contraceptives, anticoagulants, aminoglycosides
- Interference with laboratory and diagnostic tests
Contraindications
- Hypersensitivity to penicillins or excipients
- Severe gastrointestinal disorders with vomiting and diarrhea
Side Effects
- Hypersensitivity reactions
- Skin reactions
- Allergic reactions
- Anaphylactic reactions
- Skin rashes
- Gastrointestinal disturbances
- Diarrhea
- Blood picture changes
- Drug-induced meningitis
- Transient discoloration of teeth
- Proliferation of resistant microorganisms
- Encephalopathy risk
Pregnancy & Lactation
- Crosses placenta
- Safe for use throughout pregnancy
- Passes into breast milk in small amounts
- May cause diarrhoea and yeast colonization in infant
Precautions & Warnings
- Possibility of cross-allergy with cephalosporins
- Consider potassium content for patients with heart diseases or electrolyte disturbances
- Encephalopathy risk in case of overdose or renal impairment
- Proliferation of resistant microorganisms
- Check patient's condition at regular intervals
- Consider sugar content in diabetic patients
- No impairment of ability to drive or operate machinery
- Encephalopathy risk precluding machine operation or driving in case of adverse reactions
Overdose Effects
- Low toxicity
- Broad therapeutic range
- Risk of encephalopathy in case of overdose or renal impairment
- Elimination through haemodialysis
Therapeutic Class
- Benzylpenicillin
- Phenoxymethyl penicillin
Storage Conditions
- Cool and dry place
- Protected from light