Amilin 10 mg (Tablet)

Unit Price: ৳ 0.85 (8 x 14: ৳ 95.20)

Strip Price: ৳ 11.90

Medicine Details

Category	Details
Generic	Amitriptyline hydrochloride
Company	Opsonin pharma ltd
Also available as	Amilin 25 mg tablet

Indications

Depressive Illness
Nocturnal Enuresis in children
Prophylaxis of Migraine
Tension Headache
Chronic Pain

Description

Amilin is a tricyclic antidepressant with marked anticholinergic and sedative properties. It prevents the reuptake of noradrenaline and serotonin at the nerve ending. Amilin is rapidly absorbed from the Gl tract, and peak plasma concentrations occur within 2-12 hours. It is excreted in the urine, mainly in the form of its metabolites.

Pharmacology

Amitriptyline inhibits the membrane pump mechanism responsible for the re-uptake of transmitter amines, such as norepinephrine and serotonin, thereby increasing their concentration at the synaptic clefts of the brain. These amines are important in regulating mood. The monoamine hypothesis in depression postulates that deficiencies of serotonin (5-HT) and/or norepinephrine (NE) neurotransmission in the brain lead to depressive effects.

Dosage & Administration

Depression: Initially 75 mg (Elderly and Adolescents 30-75 mg) daily in divided doses or as a single dose at bedtime increased gradually as necessary to 150-200 mg; Child under 16 years not recommended for depression.
Nocturnal Enuresis: Child 7-10 years: 10-20 mg, 11-16 years: 25-50 mg at night; max. period of treatment (including gradual withdrawal) 3 months-full physical examination before the further course
Prophylaxis of Migraine: 100 mg daily
Tension Headache: 10-25 mg three times daily

Interaction

TCA enhances the sedative effect of alcohol and opioid analgesics. When TCA is used with Moxifloxacin or Terfenadine, it increases the risk of ventricular arrhythmias. Disulfiram and Cimetidine inhibit the metabolism of Amilin. When TCA is used with diuretics, it enhances the risk of postural hypotension.

Contraindications

Amitriptyline is contraindicated in myocardial infarction, arrythmias, particularly heart block of any degree, mania, and severe liver disease. Initially, sedation may affect the ability to drive or operate machinery.

Side Effects

Excessive perspiration
Dry mouth
Blurred vision
Hyperpyrexia
Urinary retention and urinary tract dilatation
Hypotension
Syncope
Postural hypotension
Hypertension
Tachycardia
Palpitations
Myocardial infarction
Confusional states
Disturbed concentration
Disorientation
Delusions
Skin rash
Urticaria
Photosensitization
Bone-marrow depression
Nausea
Epigastric distress
Vomiting
Anorexia
Stomatitis
Unpleasant taste
Weight loss
Diarrhoea
Constipation
Testicular swelling
Gynaecomastia
Breast enlargement
Galactorrhoea

Pregnancy & Lactation

Pregnancy Category: C
Use in Pregnancy: Amitriptyline should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.
Use in Lactation: Amitriptyline is excreted into breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Precautions & Warnings

It should be used with caution in patients with a history of epilepsy, glaucoma, urinary retention, cardiac disease, diabetes, pregnancy, hepatic impairment, thyroid disease, increased intra-ocular pressure and psychoses (may aggravate mania).