Amit 25 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Amitriptyline hydrochloride |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Depressive Illness
- Nocturnal Enuresis
- Prophylaxis of Migraine
- Tension Headache
- Chronic Pain
Description
A tricyclic antidepressant with marked anticholinergic and sedative properties that prevents the reuptake of noradrenaline and serotonin at the nerve ending.
Mechanism of Action
Inhibit the membrane pump mechanism responsible for the re-uptake of transmitter amines, such as norepinephrine and serotonin, increasing their concentration at the synaptic clefts of the brain.
Dosage
- Depression: 75-200 mg daily
- Nocturnal Enuresis: 10-50 mg at night
- Prophylaxis of Migraine: 100 mg daily
- Tension Headache: 10-25 mg three times daily
Interactions
- Enhances the sedative effect of alcohol and opioid analgesics
- Increases the risk of ventricular arrhythmias when used with Moxifloxacin or Terfenadine
- Inhibition of metabolism with Disulfirum and Cimetidine
- Enhanced risk of postural hypotension when used with diuretics
Contraindications
- Myocardial infarction
- Arrythmias
- Heart block of any degree
- Mania
- Severe liver disease
Side Effects
- Excessive perspiration
- Dry mouth
- Blurred vision
- Hypotension
- Confusional states
- Skin rash
- Gynaecomastia
- Nausea
- Testicular swelling
Pregnancy & Lactation
Pregnancy Category C. Excreted into breast milk. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Precautions & Warnings
Use with caution in patients with epilepsy, glaucoma, urinary retention, cardiac disease, diabetes, pregnancy, hepatic impairment, thyroid disease, increased intra-ocular pressure and psychoses
Therapeutic Class
Tricyclic Anti-depressant
Storage Conditions
Store in a cool and dry place, below 30°C. Protect from light and moisture