Reptylin 10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Amitriptyline hydrochloride |
| Company | Albion laboratories limited |
| Also available as |
Indications
- Depressive Illness: particularly where sedation is required
- Nocturnal Enuresis in children
- Prophylaxis of Migraine
- Tension Headache
- Chronic Pain
Description
Reptylin is a tricyclic antidepressant with marked anticholinergic and sedative properties. It prevents the reuptake of noradrenaline and serotonin at the nerve ending.
Mode of Action
Amitriptyline inhibits the membrane pump mechanism responsible for the reuptake of transmitter amines, such as norepinephrine and serotonin, thereby increasing their concentration at the synaptic clefts of the brain.
Dosage & Administration
- Initial dose: 75 mg daily, increased gradually as necessary
- Child Nocturnal Enuresis: 10-50 mg at night
- Prophylaxis of Migraine: 100 mg daily
- Tension Headache: 10-25 mg three times daily
Interactions
Enhances the sedative effect of alcohol and opioid analgesics, increases the risk of ventricular arrhythmias when used with Moxifloxacin or Terfenadine, and inhibits the metabolism of Reptylin when used with Disulfiram and Cimetidine.
Contraindications
- Myocardial infarction
- Arrhythmias
- Mania
- Severe liver disease
Side Effects
- Anticholinergic effects
- Cardiovascular reactions
- CNS and Neuromuscular effects
- Allergic reactions
- Haematological effects
- Gastrointestinal effects
- Endocrine effects
Pregnancy & Lactation
Pregnancy Category C. Excreted into breast milk.
Precautions & Warnings
Use with caution in patients with a history of epilepsy, glaucoma, urinary retention, cardiac disease, diabetes, pregnancy, hepatic impairment, thyroid disease, increased intra-ocular pressure, and psychoses.
Therapeutic Class
Tricyclic Anti-depressant
Storage Conditions
Store in a cool and dry place, below 30°C. Protect from light and moisture.