Flac 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 50.00

Medicine Details

Category	Details
Generic	Flucloxacillin sodium
Company	Bristol pharmaceuticals ltd
Also available as	Flac 250 mg capsule Flac 500 mg capsule

Title

Flac - Flucloxacillin

Description

Flucloxacillin is indicated for the treatment of infections due to Gram-positive organisms, including infections caused by penicillinase producing staphylococci. It is used for skin and soft tissue infections, respiratory tract infections, osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, septicaemia, and as a prophylactic agent during major surgical procedures. It is active against Gram-positive organisms including penicillinase producing strains and has little activity against Gram-negative bacilli. The dosage varies for oral and parenteral administration, with specific recommendations for adults and children. Oral doses should be administered 1 hour before a meal. Concurrent use of Flac with certain medications may result in increased levels of Flac in the blood for a prolonged period. Flucloxacillin is contraindicated in penicillin hypersensitive patients. Common side effects include gastrointestinal disturbances, rashes, urticaria, purpura, fever, interstitial nephritis, hepatitis, and cholestatic jaundice. The US FDA Pregnancy Category of Flucloxacillin is B, and it is excreted in human milk. Caution should be exercised when Flucloxacillin is administered to a lactating mother. Caution should also be exercised in patients with evidence of hepatic dysfunction and those with an allergic diathesis. In severe renal failure, a reduction in dose or an extension of dose interval should be considered. The therapeutic class is penicillinase-resistant penicillins. Flac should be kept in a dry place away from light and heat, and out of the reach of children.

Indications

Treatment of skin and soft tissue infections
Treatment of respiratory tract infections
Treatment of osteomyelitis
Treatment of enteritis
Treatment of endocarditis
Treatment of urinary tract infection
Treatment of meningitis
Prophylactic agent during major surgical procedures

Pharmacology

Active against Gram-positive organisms
Inhibits formation of bacterial cell wall
Bactericidal against penicillinase-producing staphylococci
Interferes with peptidoglycan synthesis
Resists the action of bacterial penicillinase

Dosage

Oral administration for adults: 250 mg four times daily
Oral administration for children (2-10 years): Half of adult dose
Oral administration for children (Under 2 years): Quarter of adult dose
Parenteral administration for adults: 250 mg-1 g four times daily
Parenteral administration for children: Half of adult dose or a quarter of adult dose
Doses may be doubled in severe infections

Administration

Oral doses should be administered 1 hour before meal

Interaction

Concurrent use with certain medications may result in increased level of Flac in blood for prolonged period

Contraindications

Contraindicated in penicillin hypersensitive patients

Side effects

Gastrointestinal disturbances
Rashes
Urticaria
Purpura
Fever
Interstitial nephritis
Hepatitis
Cholestatic jaundice

Pregnancy & lactation

US FDA Pregnancy Category B
Excreted in human milk
Caution should be exercised when administered to a lactating mother

Precautions & warnings

Caution in patients with evidence of hepatic dysfunction
Caution in the treatment of patients with an allergic diathesis
Reduced dose or extended dose interval in severe renal failure

Use in special populations

Consider dose reduction or extension of dose interval in severe renal failure

Therapeutic class

Penicillinase-resistant penicillins

Reconstitution

Can be administered in other routes in conjunction with systemic therapy
Can be dissolved in sterile water and inhaled by nebuliser four times daily

Storage conditions

Keep in a dry place away from light and heat
Keep out of the reach of children