Amdocal 10 mg (Tablet)
Unit Price: ৳ 8.00 (4 x 15: ৳ 480.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Essential hypertension
- Angina pectoris
- Vasospastic angina
Pharmacology
- Dihydropyridine calcium-channel blocker
- Long duration of action
- Influences myocardial cells
- Vascular smooth muscle vasodilation
- Increased coronary blood flow
- Reflex increase in coronary heart rate
Dosage & Administration
- Usual dose of 5 mg once daily
- Maximum dose of 10 mg once daily
- Lower dose for elderly patients
- May be taken without regard to meals
Interaction
- Potentially hazardous interactions with p-blockers
- No interaction with Digoxin
- No interaction with Cimetidine
- No significant alteration of effect of Warfarin on prothrombin time
- Food does not alter the rate or extent of absorption
Contraindications
- Hypersensitivity to dihydropyridine derivatives
- Pregnant woman
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Gastrointestinal disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Mental depression
- Increased ischaemic chest pain
- Excessive fall in blood pressure
- Rashes
- Fever
- Abnormalities in liver function
Pregnancy & Lactation
- Pregnancy Category C
- No adequate and well-controlled studies in pregnant women
- Recommendation to discontinue nursing while administered
Precautions & Warnings
- Precaution in patients with hepatic impairment
- Precaution during pregnancy and breastfeeding
Use in Special Populations
- Dosage recommendations for children with hypertension
- Effect on blood pressure in patients under 6 years is not known
- Normal dosage regimens recommended for elderly
- Normal dosage recommended for renal impairment
- Dosage recommendations not established for mild to moderate hepatic impairment
- Lowest initial dose for severe hepatic impairment
Overdose Effects
- Symptoms of excessive peripheral vasodilatation
- Reflex tachycardia
- Marked and prolonged systemic hypotension
- Active cardiovascular support required
- Elevation of extremities
- Attention to circulating fluid volume and urine output
- Vasoconstrictor and calcium gluconate may be beneficial
- Gastric lavage may be worthwhile
- Charcoal use can reduce absorption rate
- Dialysis not likely to be of benefit
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Keep out of reach of children
- Store in cool & dry place
- Protected from light