Phylopen DS 500 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Flucloxacillin sodium |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Skin and soft tissue infections
- Respiratory tract infections
- Osteomyelitis
- Enteritis
- Endocarditis
- Urinary tract infection
- Meningitis
- Septicaemia
- Prophylactic agent for major surgical procedures
Pharmacology
Active against Gram-positive organisms including penicillinase producing strains. Little activity against Gram-negative bacilli. Inhibits the formation of cell wall of bacteria. Bactericidal antibiotic. Useful against penicillinase-producing staphylococci.
Dosage
- Oral administrationAdult: 250 mg four times daily, may be doubled in severe infections. Up to 8 gm daily in severe cases
- Oral administrationChildren (2-10 years): 1/2 of adult dose
- Oral administrationChildren (Under 2 years): 1/4 of adult dose
- Parenteral administrationAdult or ElderlyIntramuscular Injection: 250 mg four times daily
- Parenteral administrationAdult or ElderlyIntravenous Injection: 250 mg-1 g four times daily
- Parenteral administrationChildren (2-10 years): half of the adult dose
- Parenteral administrationChildren (Under 2 years): a quarter of the adult dose
Administration
Oral doses should be administered 1 hour before meal.
Interaction
Concurrent use with certain drugs may result in increased levels of Phylopen DS in blood for prolonged period.
Contraindications
Contraindicated in penicillin hypersensitive patients.
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Dyspepsia
- Rashes
- Urticaria
- Purpura
- Fever
- Interstitial nephritis
- Hepatitis
- Cholestatic jaundice
Pregnancy & Lactation
US FDA Pregnancy Category B. Caution in use during lactation.
Precautions & Warnings
Use with caution in patients with hepatic dysfunction and allergic diathesis.
Use in Special Populations
In severe renal failure, consider a reduction in dose or an extension of dose interval.
Therapeutic Class
Penicillinase-resistant penicillins
Reconstitution
Administered in other routes in conjunction with systemic therapy. Can be administered through intraarticular and intrapleural injection. Can be inhaled by nebuliser.
Storage Conditions
Store in a dry place away from light and heat. Keep out of the reach of children.