Amdocal 5 mg (Tablet)
Unit Price: ৳ 5.50 (7 x 15: ৳ 577.00)
Strip Price: ৳ 82.43
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Essential hypertension
- Angina pectoris
- Vasospastic angina
Pharmacology
- Dihydropyridine calcium-channel blocker
- Vasodilation
- Peripheral resistance reduction
- Increased coronary blood flow
- Reflex increase in coronary heart rate
Dosage & Administration
- Usual dose: 5 mg once daily
- Maximum dose: 10 mg once daily
- Lower dose for elderly and hepatic insufficiency
Interaction
- Potentially hazardous interactions with p-blockers
- No interaction with Digoxin
- No interaction with Cimetidine
- No significant alteration of Warfarin effect
- Food does not alter absorption rate
Contraindications
- Hypersensitivity to dihydropyridine derivatives
- Pregnancy
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Gastrointestinal disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Mental depression
- Paradoxical increase in ischaemic chest pain
- Excessive fall in blood pressure
- Rashes
- Fever
- Abnormalities in liver function
Pregnancy & Lactation
Pregnancy Category C
Precautions & Warnings
- Hepatic impairment caution
- Pregnancy caution
- Breastfeeding caution
Use in Special Populations
- Dosage adjustment for children
- Normal dosage regimens for elderly
- No correlation between amlodipine plasma concentrations and renal impairment
- Caution in dosage selection for mild to moderate hepatic impairment
- Initiation at lowest dose for severe hepatic impairment
Overdose Effects
- Excessive peripheral vasodilatation
- Reflex tachycardia
- Systemic hypotension up to shock
- Active cardiovascular support required
- Attention to circulating fluid volume and urine output
- Management with vasoconstrictor, calcium gluconate, gastric lavage, and charcoal use
- Dialysis not likely to be beneficial
Therapeutic Class
Calcium-channel blockers
Storage Conditions
Keep in cool & dry place, protected from light