Skilox 500 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Flucloxacillin sodium |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Skin and soft tissue infections: Boils, abscess, carbuncles, infected skin conditions (e.g. ulcer, eczema, acne, furunculosis, cellulitis, infected wounds, infected burns, otitis media and externa, impetigo)
- Respiratory tract infections: Pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, quinsy
- Osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, septicaemia
- Prophylactic agent for major surgical procedures (e.g. cardiothoracic and orthopedic surgery)
Pharmacology
Flucloxacillin is active against Gram-positive organisms including penicillinase producing strains. It has little activity against Gram-negative bacilli. Flucloxacillin acts by inhibiting the formation of cell wall of bacteria.
Dosage
- Oral administration:
- Adult: 250 mg four times daily. Dosage may be doubled in severe infections. In osteomyelitis and endocarditis, up to 8 gm daily is used in 6-8 hourly divided doses
- Children (2-10 years): 1/2 of adult dose
- Children (Under 2 years): 1/4 of adult dose
- Parenteral administration:
- Adult or Elderly: Intramuscular Injection - 250 mg four times daily
- Intravenous Injection: 250 mg-1 g four times daily by slow injection over 3 to 4 minutes or by intravenous infusion
- Children (2-10 years): half of the adult dose
- Children (Under 2 years): a quarter of the adult dose
Administration
Oral doses should be administered 1 hour before meal
Interaction
Concurrent use of Skilox and may result in increased level of Skilox in blood for prolonged period
Contraindications
Flucloxacillin is contraindicated in penicillin hypersensitive patients
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Dyspepsia
- Rashes
- Urticaria
- Purpura
- Fever
- Interstitial nephritis
- Hepatitis
- Cholestatic jaundice
Pregnancy & Lactation
US FDA Pregnancy Category B. Caution should be exercised when Flucloxacillin is administered to a lactating mother
Precautions & Warnings
- Use with caution in patients with evidence of hepatic dysfunction
- Caution should be exercised in the treatment of patients with an allergic diathesis
Use in Special Populations
In severe renal failure (creatinine clearance <10 ml/min), a reduction in dose or an extension of dose interval should be considered
Therapeutic Class
Penicillinase-resistant penicillins
Reconstitution
Skilox has been used in other routes in conjunction with systemic therapy. It has been administered in a dose of 250 mg to 500 mg daily by intraarticular injection, dissolved if necessary in a 0.5% solution of lignocaine hydrochloride, and by intrapleural injection in a dose of 250 mg daily. Using powder for injection, 125 mg-250 mg has been dissolved in 3 ml of sterile water and inhaled by nebuliser four times daily
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children