Amox 500 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Amoxicillin trihydrate |
| Company | Doctors chemical works ltd |
| Also available as |
Indications
- Ear, nose and throat infections
- Lower respiratory tract infections
- Skin and soft tissue infections
- Genito-urinary tract infections
- Venereal disease
- Dental abscess
- H. pylori infection and duodenal ulcer disease
Pharmacology
Effective against a wide range of Gram-positive and Gram-negative bacteria, acts through the inhibition of biosynthesis of cell wall, stable in the presence of gastric acid, rapidly absorbed after oral administration, widely distributed in body tissues and fluids
Dosage
- Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections
- Children: 125 mg three times daily, increasing up to 250 mg three times daily for severe infections
- Special Cases:
- Severe or recurrent purulent respiratory infection: 3 gm every 12 hours
- Otitis media: 1 g three times daily for adults, 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily)
- Pneumonia: 500-1000 mg three times daily
- Dental abscess: 3 gm, repeated after 10-12 hours
- Urinary tract infections: 3 gm, repeated after 10-12 hours
- Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm
- Renal impairment may require reduction in total daily dosage
Administration
Reconstituted suspension can be administered by adding the required amount of suspension to milk, fruit juice, or water
Interaction
- Concurrent use of Amox and Probenecid may result in increased and prolonged blood levels of Amox
- Amox may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives
Contraindications
Contraindicated in penicillin hypersensitive patients
Side Effects
- Diarrhoea
- Indigestion
- Rash
- Pseudo-membranous colitis (rare)
Pregnancy & Lactation
US FDA pregnancy category B, excreted in human milk, caution should be exercised when administered to a lactating mother
Precautions & Warnings
The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy, appropriate therapy should be instituted if superinfections occur
Therapeutic Class
Broad spectrum penicillins
Reconstitution
- Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial
- Intravenous: Dissolve Amoxycillin 500 mg injection in 10 ml water for injection
Storage Conditions
Keep in a dry place away from light and heat, keep out of the reach of children