Amlopin 5 mg (Tablet)
Unit Price: ৳ 5.01 (5 x 10: ৳ 250.50)
Strip Price: ৳ 50.10
Medicine Details
Category | Details |
---|---|
Generic | Amlodipine besilate |
Company | Acme laboratories ltd |
Also available as |
Indications
- Essential hypertension
- Angina pectoris
- Vasospastic angina
Pharmacology
- Dihydropyridine calcium-channel blocker
- Long duration of action
- Vasodilation
- Reduced peripheral resistance
- Increased coronary blood flow
- Reflex increase in coronary heart rate
- Increased myocardial oxygen supply
- Cardiac output
Dosage & Administration
- Usual dose 5 mg once daily for hypertension
- Maximum dose 10 mg once daily for hypertension
- 5 to 10 mg for angina
- May be taken without regard to meals
Interaction
- Potentially hazardous interactions with p-blockers
- No interaction with Digoxin
- No interaction with Cimetidine
- No significant alteration with Warfarin
- Food does not alter absorption
Contraindications
- Hypersensitivity to dihydropyridine derivatives
- Pregnancy
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Gastrointestinal disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Mental depression
- Paradoxical increase in ischaemic chest pain
- Excessive fall in blood pressure
- Rashes
- Fever
- Abnormalities in liver function
Pregnancy & Lactation
- Pregnancy Category C
- Use during pregnancy if potential benefit justifies potential risk
- Recommended to discontinue nursing while administered
Precautions & Warnings
- Precaution in patients with hepatic impairment
- Precaution during pregnancy and breastfeeding
Use in Special Populations
- Different doses for children and elderly
- Normal dosage regimens recommended for the elderly
- Normal dosage recommended for renal impairment
- Caution in patients with hepatic impairment
- Initiate at lowest dose for severe hepatic impairment
Overdose Effects
- Excessive peripheral vasodilatation
- Possibly reflex tachycardia
- Marked and prolonged systemic hypotension
- Active cardiovascular support required
- Vasoconstrictor may be helpful
- Intravenous calcium gluconate may be beneficial
- Gastric lavage may be worthwhile
- Use of charcoal shown to reduce absorption rate
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Keep out of reach of children
- Store in cool & dry place
- Protected from light