Amlopin 5 mg (Tablet)

Unit Price: ৳ 5.01 (5 x 10: ৳ 250.50)
Strip Price: ৳ 50.10

Medicine Details

Category Details
Generic Amlodipine besilate
Company Acme laboratories ltd
Also available as

Indications

  • Essential hypertension
  • Angina pectoris
  • Vasospastic angina

Pharmacology

  • Dihydropyridine calcium-channel blocker
  • Long duration of action
  • Vasodilation
  • Reduced peripheral resistance
  • Increased coronary blood flow
  • Reflex increase in coronary heart rate
  • Increased myocardial oxygen supply
  • Cardiac output

Dosage & Administration

  • Usual dose 5 mg once daily for hypertension
  • Maximum dose 10 mg once daily for hypertension
  • 5 to 10 mg for angina
  • May be taken without regard to meals

Interaction

  • Potentially hazardous interactions with p-blockers
  • No interaction with Digoxin
  • No interaction with Cimetidine
  • No significant alteration with Warfarin
  • Food does not alter absorption

Contraindications

  • Hypersensitivity to dihydropyridine derivatives
  • Pregnancy

Side Effects

  • Dizziness
  • Flushing
  • Headache
  • Hypotension
  • Peripheral edema
  • Gastrointestinal disturbances
  • Increased micturition frequency
  • Lethargy
  • Eye pain
  • Mental depression
  • Paradoxical increase in ischaemic chest pain
  • Excessive fall in blood pressure
  • Rashes
  • Fever
  • Abnormalities in liver function

Pregnancy & Lactation

  • Pregnancy Category C
  • Use during pregnancy if potential benefit justifies potential risk
  • Recommended to discontinue nursing while administered

Precautions & Warnings

  • Precaution in patients with hepatic impairment
  • Precaution during pregnancy and breastfeeding

Use in Special Populations

  • Different doses for children and elderly
  • Normal dosage regimens recommended for the elderly
  • Normal dosage recommended for renal impairment
  • Caution in patients with hepatic impairment
  • Initiate at lowest dose for severe hepatic impairment

Overdose Effects

  • Excessive peripheral vasodilatation
  • Possibly reflex tachycardia
  • Marked and prolonged systemic hypotension
  • Active cardiovascular support required
  • Vasoconstrictor may be helpful
  • Intravenous calcium gluconate may be beneficial
  • Gastric lavage may be worthwhile
  • Use of charcoal shown to reduce absorption rate

Therapeutic Class

  • Calcium-channel blockers

Storage Conditions

  • Keep out of reach of children
  • Store in cool & dry place
  • Protected from light

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