Amocal 10 mg (Tablet)

Unit Price: ৳ 6.04 (3 x 14: ৳ 253.68)

Strip Price: ৳ 84.56

Medicine Details

Category	Details
Generic	Amlodipine besilate
Company	Opsonin pharma ltd
Also available as	Amocal 5 mg tablet

Indications

Essential hypertension
Angina pectoris
Vasospastic angina

Pharmacology

Amlodipine is a dihydropyridine calcium-channel blocker with long duration of action used for the treatment of hypertension and angina pectoris.

Dosage & Administration

Usual dose is 5 mg once daily for hypertension
5 to 10 mg for angina
May be taken without regard to meals

Interaction

Potentially hazardous interactions: Combination of Amocal and β-blockers should be avoided in patients with markedly impaired cardiac left ventricular function
Other Significant Interactions:
- No interaction between Amocal and Digoxin
- No interaction between Amocal and Cimetidine
- Amocal did not significantly alter the effect of Warfarin on prothrombin time
- Food does not alter the rate or extent of absorption of Amocal

Contraindications

Hypersensitivity to dihydropyridine derivatives
Pregnant woman

Side Effects

Dizziness
Flushing
Headache
Hypotension
Peripheral edema
Gastrointestinal disturbances
Increased micturition frequency
Lethargy
Eye pain
Mental depression
Paradoxical increase in ischaemic chest pain
Excessive fall in blood pressure
Rashes
Fever
Abnormalities in liver function

Pregnancy & Lactation

Pregnancy Category C. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Amlodipine is excreted in human milk.

Precautions & Warnings

Precaution should be taken in patients with hepatic impairment and during pregnancy and breastfeeding.

Use in Special Populations

Children with hypertension from 6 years to 17 years of age: 2.5 mg once daily as a starting dose, up-titrated to 5 mg once daily if blood pressure goal is not achieved after 4 weeks
Children under 6 years old: The effect of amlodipine on blood pressure in patients less than 6 years of age is not known
Elderly: Amocal used at similar doses in elderly or younger patients is equally well tolerated
Renal impairment: Normal dosage recommended
Hepatic impairment: Dosage recommendations have not been established in patients with mild to moderate hepatic impairment

Overdose Effects

Symptoms: Excessive peripheral vasodilatation, reflex tachycardia, marked systemic hypotension up to shock
Management: Active cardiovascular support, elevation of extremities, attention to circulating fluid volume and urine output, vasoconstrictor, intravenous calcium gluconate, gastric lavage, use of charcoal, dialysis is not likely to be of benefit