Tymox 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 47.14

Medicine Details

Category Details
Generic Amoxicillin trihydrate
Company Somatec pharmaceuticals ltd
Also available as
Tymox 500 mg capsule Tymox 125 mg pediatric drop

Indications

  • Treatment of infections due to susceptible ß-lactamase negative strains of microorganisms
  • Ear, nose and throat infections
  • Lower respiratory tract infections
  • Skin and soft tissue infections
  • Genito-urinary tract infections
  • Venereal disease
  • Dental abscess
  • H. pylori infection and duodenal ulcer disease
  • Reduction of duodenal ulcer recurrence

Pharmacology

Amoxicillin is a broad spectrum penicillin effective against a wide range of Gram-positive and Gram-negative bacteria. It inhibits the biosynthesis of the cell wall, is stable in gastric acid, and rapidly absorbed after oral administration.

Dosage

  • Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections
  • Children: 125 mg three times daily, increasing up to 250 mg three times daily for severe infections
  • Special Cases:
    • Severe or recurrent purulent respiratory infection: 3 gm every 12 hours
    • Otitis media: Recommended dose is 1 g three times daily for adults and 40 mg/kg body weight daily in 3 divided doses for children
    • Pneumonia: Recommended dose is 500-1000 mg three times daily
    • Dental abscess: Recommended dose is 3 gm, repeated after 10-12 hours
    • Urinary tract infections: Recommended dose is 3 gm, repeated after 10-12 hours
    • Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended
    • Renal impairment: Total daily dosage may need reduction

Administration

Reconstituted suspension can be administered by adding the required amount of suspension to milk, fruit juice, or water, and taken immediately.

Interaction

  • Concurrent use of Tymox and Probenecid may result in increased and prolonged blood levels of Tymox
  • Tymox may affect gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives

Contraindications

Amoxicillin is contraindicated in penicillin hypersensitive patients.

Side Effects

  • Diarrhea
  • Indigestion
  • Rash
  • Pseudo-membranous colitis reported rarely

Pregnancy & Lactation

US FDA pregnancy category of Amoxicillin is B. Caution should be exercised when Amoxicillin is administered to a lactating mother.

Precautions & Warnings

Possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Tymox should be discontinued and appropriate therapy should be instituted.

Therapeutic Class

Broad spectrum penicillins

Reconstitution

  • Amoxycillin 500 mg Injection:
    • Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial
    • Intravenous: Dissolve Amoxycillin 500 mg injection in 10 ml water for injection

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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