Brodactam (4 gm+0.5 gm)/vial (IV Infusion)

4.5 gm vial: ৳ 1,003.00

Medicine Details

Category	Details
Generic	Piperacillin tazobactam
Company	Synovia pharma plc
Also available as	Brodactam 2 gm injection

Indications

Intra-abdominal Infections
Skin and Skin Structure Infections
Community-acquired pneumonia
Nosocomial pneumonia

Pharmacology

Piperacillin is a broad-spectrum penicillin active against many gram-positive and gram-negative bacteria. Tazobactam is a potent inhibitor of beta-lactamases.

Dosage & Administration

Adult Patients: 3.375 g every six hours totaling 13.5 g
Nosocomial Pneumonia: 4.5 g every six hours plus an aminoglycoside totaling 18.0 g
Pediatric Patients: Dosage based on body weight and age

Interactions

Aminoglycosides
Probenecid
Anticoagulants
Vecuronium
Methotrexate

Contraindications

Allergic reactions to penicillins, cephalosporins, or beta-lactamase inhibitors

Side Effects

Skin reactions
Gastrointestinal issues
Immune hypersensitivity reactions
Metabolic disorders
Musculoskeletal disorders
Respiratory issues

Pregnancy & Lactation

Limited data on impact in pregnant women and breastfeeding

Precautions & Warnings

Serious hypersensitivity reactions
Severe cutaneous adverse reactions
Hematological effects
Nephrotoxicity
Clostridium difficile associated diarrhea

Use in Special Populations

Pediatric Use
Geriatric Use
Renal Impairment
Hepatic Impairment
Patients with Cystic Fibrosis

Overdose Effects

Neuromuscular excitability or convulsions if higher than recommended doses

Therapeutic Class

Broad spectrum penicillins
Other beta-lactam Antibiotics

Reconstitution

Vial reconstitution for intravenous infusion

Storage Conditions

Keep below 30°C temperature, away from light & moisture