Tazocilin (4 gm+0.5 gm)/vial (IV Infusion)
4.5 gm vial: ৳ 1,003.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Piperacillin tazobactam |
| Company | Square pharmaceuticals plc |
| Also available as |
Title
- Piperacillin and Tazobactam Injection
Categories
- Medicine
- Antibiotic
- Pharmacology
Indications
- Intra-abdominal infections treatment
- Skin and skin structure infections treatment
- Community-acquired pneumonia treatment
- Nosocomial pneumonia treatment
- Postpartum endometritis treatment
Pharmacology
- Broad spectrum antibacterial activity
- Bactericidal activity
- Inhibition of cell wall synthesis
- Inhibition of beta-lactamases
- Enhancement of antibiotic spectrum
Dosage & Administration
- Administered by intravenous infusion
- Usual total daily dose for adults is 3.375g
- Treatment duration of 7 to 10 days for adults
- Initial presumptive treatment for nosocomial pneumonia
- Dosage adjustment for pediatric patients based on age and weight
Interaction
- Potential interaction with aminoglycosides
- Potential interaction with probenecid
- Coagulation parameters testing for anticoagulant interaction
- Potential interaction with vecuronium
- Potential interaction with methotrexate
Contraindications
- Contraindicated in patients with history of allergic reactions to penicillins, cephalosporins, or beta-lactamase inhibitors
Side Effects
- Adverse events involving skin, gastrointestinal, and general disorders
- Immune hypersensitivity reactions
- Infections, metabolism, and musculoskeletal disorders
- Psychiatric and vascular disorders
- Respiratory, thoracic, and mediastinal disorders
Pregnancy & Lactation
- Crosses the placenta in humans
- Insufficient data on risk for major birth defects and miscarriage
- Excretion in human milk
- No data on effects on breastfed child
Precautions & Warnings
- Serious hypersensitivity reactions reported
- Potential severe cutaneous adverse reactions
- Hematological effects monitoring
- Nephrotoxicity in critically ill patients
- Clostridium difficile associated diarrhea evaluation
Use in Special Populations
- Supported use in pediatric patients
- Dosage adjustment in geriatric patients and patients with renal impairment
- No dosage adjustment needed in hepatic impairment
- Increased incidence of fever and rash in cystic fibrosis patients
Overdose Effects
- Reported overdose events including nausea, vomiting, and diarrhea
- Potential neuromuscular excitability or convulsions
Therapeutic Class
- Broad spectrum penicillins
- Other beta-lactam Antibiotics
Reconstitution
- Administration by intravenous infusion over 30 minutes
- Withdrawal and mixing process with Sodium Chloride solution
- Immediate use after reconstitution
- Storage and discard guidelines
Storage Conditions
- Keep below 30°C temperature
- Protect from light and moisture
- Keep out of the reach of children