Tazobac (2 gm+0.25 gm)/vial (IV Infusion)
2.25 gm vial: ৳ 601.80
Medicine Details
| Category | Details |
|---|---|
| Generic | Piperacillin tazobactam |
| Company | Aci limited |
| Also available as |
Indications
- Treatment of moderate to severe infections caused by susceptible isolates of designated bacteria
- Intra-abdominal infections
- Skin and skin structure infections
- Female pelvic infections
- Community-acquired pneumonia
- Nosocomial pneumonia
Pharmacology
- Bactericidal activity against gram-positive and gram-negative bacteria
- Inhibition of septum and cell wall synthesis
- Enhancement and extension of antibiotic spectrum
Dosage & Administration
- Administered by intravenous infusion over 30 minutes
- Usual total daily dose for adults and pediatric patients
- Different dosage for nosocomial pneumonia
- Dosage adjustment for pediatric patients with renal impairment
Interaction
- Inactivation of aminoglycosides
- Sequential administration with tobramycin
- Probenecid prolongs half-life
- Effects on coagulation parameters
- Prolongation of neuromuscular blockade
- Competition for renal secretion with methotrexate
Contraindications
- Allergic reactions to penicillins, cephalosporins, or β-lactamase inhibitors
Side Effects
- Skin-related adverse events
- Gastrointestinal adverse events
- General disorders and administration site conditions
- Immune hypersensitivity reactions
- Metabolism and nutrition disorders
- Musculoskeletal and connective tissue disorders
- Psychiatric disorders
- Vascular disorders
- Respiratory, thoracic, and mediastinal disorders
Pregnancy & Lactation
- Crosses placenta in humans
- Insufficient data on drug-associated risk for major birth defects and miscarriage
- Excretion in human milk
- Effects on the breastfed child and milk production
Precautions & Warnings
- Serious hypersensitivity reactions
- Severe cutaneous adverse reactions
- Hematological effects
- Nephrotoxicity in critically ill patients
- Clostridium difficile associated diarrhea
Use in Special Populations
- Pediatric use
- Geriatric use
- Renal impairment
- Hepatic impairment
- Patients with cystic fibrosis
Overdose Effects
- Nausea, vomiting, and diarrhea
- Neuromuscular excitability or convulsions
- Supportive and symptomatic treatment
Therapeutic Class
- Broad spectrum penicillins
- Other beta-lactam antibiotics
Reconstitution
- Reconstitution details for intravenous infusion
- Storage instructions before and after reconstitution
Storage Conditions
- Temperature and environmental storage considerations