Calchek 5 mg (Tablet)
Unit Price: ৳ 5.01 (5 x 10: ৳ 250.50)
Strip Price: ৳ 50.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate |
| Company | General pharmaceuticals ltd |
Indications
- Essential hypertension
- Angina pectoris
- Vasospastic angina
Pharmacology
- Dihydropyridine calcium-channel blocker
- Vasodilation
- Myocardial oxygen supply
- Coronary blood flow
- Cardiac output
Dosage & Administration
- Usual dose is 5 mg once daily
- Maximum dose is 10 mg once daily
- May be taken without regard to meals
Interaction
- Potentially hazardous interactions with p-blockers in patients with impaired cardiac left ventricular function
- No interaction with Digoxin documented in clinical study
- No interaction with Cimetidine in healthy volunteers
- No significant alteration of Warfarin effect on prothrombin time
- Food does not alter the absorption
Contraindications
- Hypersensitivity to dihydropyridine derivatives
- Pregnant women
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Gastrointestinal disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Mental depression
- Paradoxical increase in ischaemic chest pain
- Excessive fall in blood pressure
- Rashes
- Fever
- Abnormalities in liver function
Pregnancy & Lactation
- Pregnancy Category C
- Use only if potential benefit justifies potential risk to fetus
- Recommendation to discontinue nursing
Precautions & Warnings
- Precaution in patients with hepatic impairment, pregnancy, and breastfeeding
Use in Special Populations
- Specific dosing for children with hypertension from 6 to 17 years of age
- Limited information on the effect on blood pressure in patients less than 6 years old
- Normal dosage regimens recommended in the elderly
- Recommended normal dosage in renal impairment
- Caution in dosage selection for mild to moderate hepatic impairment
- Initiation at lowest dose and slow titration in severe hepatic impairment
Overdose Effects
- Excessive peripheral vasodilatation
- Reflex tachycardia
- Marked and prolonged systemic hypotension
- Clinically significant hypotension calls for active cardiovascular support
- Elevation of extremities
- Attention to circulating fluid volume and urine output
- Use of vasoconstrictor and intravenous calcium gluconate for management
- Possibility of benefit from gastric lavage and charcoal use
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Keep out of reach of children
- Store in a cool & dry place
- Protected from light