Calock 10 mg (Tablet)
Unit Price: ৳ 3.75 (50's pack: ৳ 187.50)
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate |
| Company | Medimet pharmaceuticals ltd |
| Also available as |
Indications
- Essential hypertension
- Angina pectoris
- Vasospastic angina
Pharmacology
- Dihydropyridine calcium-channel blocker
- Long duration of action
- Influences myocardial cells
- Vasodilation
- Reduced peripheral resistance
- Increased coronary blood flow
Dosage & Administration
- Usual dose is 5 mg once daily for hypertension
- Maximum dose is 10 mg once daily
- Lower dose for elderly and hepatic insufficiency
- May be taken without regard to meals
Interaction
- Potentially hazardous interactions with p-blockers
- No interaction with Digoxin
- No interaction with Cimetidine
- No significant alteration with Warfarin
- Food does not alter absorption
Contraindications
- Hypersensitivity to dihydropyridine derivatives
- Pregnancy
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Gastrointestinal disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Mental depression
- Ischaemic chest pain
- Excessive fall in blood pressure
- Rashes
- Fever
- Abnormalities in liver function
Pregnancy & Lactation
- Pregnancy Category C
- No adequate and well-controlled studies
- Use only if potential benefit justifies risk
- Recommendation to discontinue nursing
Precautions & Warnings
- Hepatic impairment
- Pregnancy
- Breast feeding
Use in Special Populations
- Dosage for children with hypertension
- Effect on blood pressure in patients under 6 years is not known
- Elderly tolerance
- No correlation with renal impairment
- Dosing range for hepatic impairment
Overdose Effects
- Excessive peripheral vasodilatation
- Reflex tachycardia
- Marked and prolonged systemic hypotension
- Active cardiovascular support
- Elevation of extremities
- Attention to circulating fluid volume
- Vasoconstrictor may be helpful
- Intravenous calcium gluconate may be beneficial
- Gastric lavage may be worthwhile
- Use of charcoal for reduction of absorption rate
Therapeutic Class
Calcium-channel blockers
Storage Conditions
Store in a cool & dry place, protected from light