Aphrin 500 mg (Capsule)

Unit Price: ৳ 12.00 (3 x 7: ৳ 252.00)
Strip Price: ৳ 84.00

Medicine Details

Category Details
Generic Cephradine
Company Apex pharmaceuticals ltd
Also available as
Aphrin 125 mg suspension

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections like sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis
  • Lower respiratory tract infections like bronchitis, lobar pneumonia, bronchopneumonia
  • Urinary tract infections including cystitis, urethritis, pyelonephritis
  • Skin and soft tissue infections such as abscess, cellulitis, furunculosis, impetigo

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in bacterial cell wall

Dosage & Administration

  • Oral administration for adults and children
  • Dosage adjustment necessary in renal impairment
  • Injectable administration for adults and children

Interaction

  • Risk of kidney damage when used concomitantly with nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Not to be used in patients with known hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Blood disorders
  • Immune system disorders
  • Psychiatric disorders
  • Nervous system disorders
  • Hepatobiliary disorders
  • Renal and urinary disorders
  • Elevation of blood urea nitrogen, serum creatinine, alanine aminotransferase, aspartate aminotransferase, total bilirubin, alkaline phosphatase

Pregnancy & Lactation

  • Safety in pregnancy not established, caution in lactating mothers

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Administered with care to patients hypersensitive to penicillins
  • May cause false positive urine glucose result

Use in Special Populations

  • Recommended doses for patients with renal impairment

Overdose Effects

  • Non-specific symptoms of nausea, vomiting, diarrhoea, gastric upsets

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Reconstituted Suspension should be used within 7-14 days

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