Aphrin 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 80.00

Medicine Details

Category Details
Generic Cephradine
Company Apex pharmaceuticals ltd
Also available as
Aphrin 500 mg capsule

Indications

  • Treatment of upper respiratory tract infections
  • Treatment of lower respiratory tract infections
  • Treatment of urinary tract infections
  • Treatment of skin and soft tissue infections
  • Susceptibility to specific microorganisms

Pharmacology

  • Broad-spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in the cell wall of bacteria
  • Lysis of bacteria due to external osmotic pressure

Dosage & Administration

  • Recommended oral dosage for adults and children
  • Maximum daily dosage
  • Dosage for injectable administration in adults and children
  • Dosage adjustments for elderly and patients with impaired renal or hepatic function

Interaction

  • Potential risk of kidney damage when used with nephrotoxic drugs
  • Enhanced renal toxicity when used with diuretics and probenecid

Contraindications

  • Not to be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Gastrointestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Possible blood and lymphatic system disorders
  • Possible immune system disorders
  • Possible psychiatric disorders
  • Possible nervous system disorders
  • Possible hepatobiliary disorders
  • Possible renal and urinary disorders
  • Possible investigations-related issues

Pregnancy & Lactation

  • Unestablished safety in pregnancy
  • Excretion in breast milk
  • Caution in lactating mothers
  • Potential to cause dizziness

Precautions & Warnings

  • Development of superinfection due to prolonged use
  • Administration with care to penicillin-hypersensitive patients
  • Potential positive result in Coombs’ testing
  • Potential false positive urine glucose result
  • Necessity of dosage adjustment in renal impairment
  • Lactose content concerns for patients with specific hereditary problems

Use in Special Populations

  • Recommended doses for patients with renal impairment
  • Additional information for all patients
  • Monitoring and treatment duration recommendations
  • Transfer from intramuscular/intravenous therapy to oral treatment

Overdose Effects

  • Non-specific symptoms
  • Supportive treatment
  • Necessity of gastric lavage for large ingestions

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Reconstituted suspension shelf life
  • Injection solution shelf life
  • Effect of storage temperature on potency
  • Variation in reconstituted solution color
  • Dispensing only on prescription

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