Avlosef DS 250 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 135.41

Medicine Details

Category Details
Generic Cephradine
Company Aci limited
Also available as
Avlosef 250 mg capsule Avlosef 500 mg capsule Avlosef 125 mg pediatric drop Avlosef 1 gm injection Avlosef 125 mg suspension

Title and Categories

  • Avlosef DS
  • Antibiotics
  • Cephalosporins
  • First generation Cephalosporins

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in bacteria cell walls
  • Cell wall lysis due to external osmotic pressure

Dosage & Administration

  • Oral administration for adults and children
  • Injectable administration for adults and children
  • Dosage adjustment for elderly and patients with impaired renal or hepatic function

Interaction

  • Concomitant use of nephrotoxic drugs may increase risk of kidney damage
  • Diuretics and probenecid enhance possibility of renal toxicity

Contraindications

  • Not to be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Blood disorders
  • Fever
  • Serum sickness like reactions
  • Anaphylaxis
  • Liver enzyme disturbances
  • Reversible interstitial nephritis

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excretion in breast milk
  • Caution in lactating mothers
  • Caution about operating hazardous machinery for patients

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Administration with care to patients hypersensitive to penicillins
  • Cephalosporin antibiotics may cause a positive result in Coombs’ testing
  • May cause false positive urine glucose result with certain test solutions
  • Dosage adjustment necessary in renal impairment
  • Contains lactose, not suitable for patients with specific hereditary problems

Use in Special Populations

  • Recommended doses for patients not on haemodialysis
  • Recommendations for patients on chronic, intermittent haemodialysis
  • Higher doses may be required for chronic or severe infections
  • Monitoring required for chronic urinary tract infections
  • Paediatric dosages should not exceed those specified for adults

Overdose Effects

  • Non-specific symptoms including nausea, vomiting, diarrhea, and gastric upsets
  • Supportive treatment
  • Gastric lavage necessary in case of large ingestion

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Suspension should be freshly prepared
  • Reconstituted Suspension should be used within 7-14 days based on storage
  • Injection solutions should be used within 2 hours when kept at room temperature
  • Retain potency for 12 hours when stored at 5°C
  • Do not use later than the date of expiry
  • Keep out of the reach of children
  • To be dispensed only on the prescription of a registered physician

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