Betasef 500 mg (Capsule)

Product Title and Categories

• Betasef
• Antibiotic
• Medicine
• First generation Cephalosporins

Indications

• Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
• Upper respiratory tract infections (sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis, otitis media)
• Lower respiratory tract infections (bronchitis, lobar pneumonia, bronchopneumonia)
• Urinary tract infections (cystitis, urethritis, pyelonephritis)
• Skin and soft tissue infections (abscess, cellulitis, furunculosis, impetigo)

Pharmacology

• Semisynthetic broad spectrum bactericidal antibiotic
• Active against gram-positive and gram-negative microorganisms
• Inhibits cross-linking process in bacterial cell wall

Dosage and Administration

• Oral administration for adults and children
• Injectable administration for adults and children
• Dosage adjustment in renal impairment
• Maximum daily dosage: 4 gm

Interactions

• Nephrotoxic drugs may increase the risk of kidney damage
• Diuretics and probenecid enhance renal toxicity

Contraindications

• Hypersensitivity to cephalosporins

Side Effects

• Gastro-intestinal disturbances
• Hypersensitivity phenomena
• Skin reactions
• Glossitis, heartburn, dizziness, nausea, vomiting, diarrhoea, abdominal pain, vaginitis, candida overgrowth
• Rare blood disorders, immune system disorders, psychiatric disorders, nervous system disorders, hepatobiliary disorders, renal and urinary disorders
• Elevation of blood urea nitrogen, serum creatinine, liver enzymes

Pregnancy and Lactation

• Teratogenicity not demonstrated in animal studies
• Caution advised for lactating mothers
• Patients cautioned about operating hazardous machinery

Precautions and Warnings

• Prolonged use may result in superinfection
• Care in patients hypersensitive to penicillins
• Potential positive result in Coombs’ testing
• May cause a false positive urine glucose result with certain testing methods
• Dosage adjustment necessary in renal impairment
• Contains lactose, not suitable for certain patients

Use in Special Populations

• Recommended doses for patients with renal impairment and on haemodialysis
• Higher doses may be required for chronic or severe infections
• Regular bacteriological and clinical monitoring for urinary tract infections
• Paediatric dosages should not exceed those specified for adults

Overdose Effects

• Non-specific symptoms such as nausea, vomiting, diarrhoea, and gastric upsets
• Supportive treatment advised
• Gastric lavage may be necessary in case of large ingestion

Therapeutic Class

• First generation Cephalosporins

Storage Conditions

• Suspension should be freshly prepared
• Reconstituted Suspension should be used within designated timeframes
• Injection solutions retain potency for specific durations
• Do not use after the date of expiry
• Keep out of reach of children
• To be dispensed only on the prescription of a registered physician

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