Brace 500 mg (Capsule)

Unit Price: ৳ 12.05 (20's pack: ৳ 241.00)

Medicine Details

Category Details
Generic Cephradine
Company Hallmark pharmaceuticals ltd
Also available as
Brace 250 mg capsule Brace 125 mg suspension

Indications

  • Treatment of infections caused by Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections like sinusitis, pharyngitis, tonsillitis, and otitis media
  • Lower respiratory tract infections like bronchitis and pneumonia
  • Urinary tract infections like cystitis, urethritis, and pyelonephritis
  • Skin and soft tissue infections like abscess and cellulitis

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in bacteria cell wall
  • Bactericidal action due to lysis of bacteria

Dosage & Administration

  • Oral Administration - Adults:
    • 500mg four times daily for urinary tract infections
    • 250 to 500mg four times daily for respiratory tract infections
    • 250 to 500mg four times daily for skin and soft tissue infections
  • Oral Administration - Children:
    • Total daily dose of 25 to 50mg/kg for general infections
    • Total daily dose of 75 to 100mg/kg for otitis media
    • Maximum daily dosage: 4 gm
  • Injectable Administration - Adult: 2-4 gm daily in four equally divided doses
  • Injectable Administration - Children: 50-100 mg/kg daily in four equally divided doses

Interaction

Increased risk of kidney damage when used with nephrotoxic drugs

Contraindications

Not to be used in patients with known hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Rare: Glossitis, heartburn, dizziness, nausea, vomiting, diarrhoea, urticaria, joint pains, oedema

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excreted in breast milk
  • Caution advised in lactating mothers

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Administered with care to patients hypersensitive to penicillins
  • May cause false positive urine glucose result
  • Dosage adjustment necessary in renal impairment

Use in Special Populations

Dosing recommendations for patients with renal impairment

Overdose Effects

Non-specific symptoms like nausea, vomiting, diarrhoea

Therapeutic Class

First generation Cephalosporins

Storage Conditions

Reconstituted Suspension and Injection solutions have specific storage timelines

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