Ceframed 250 mg (Capsule)

Unit Price: ৳ 7.00 (50's pack: ৳ 350.00)

Medicine Details

Category	Details
Generic	Cephradine
Company	Medimet pharmaceuticals ltd
Also available as	Ceframed 500 mg capsule Ceframed 125 mg suspension Ceframed 125 mg pediatric drop

Indications

treatment of upper respiratory tract infections
treatment of lower respiratory tract infections
treatment of urinary tract infections
treatment of skin and soft tissue infections
sensitive to Gram-positive bacteria
sensitive to Gram-negative bacteria

Pharmacology

semisynthetic broad spectrum bactericidal antibiotic
active against both gram-positive and gram-negative microorganisms
inhibits cross-linking process in cell wall of bacteria
lysis of bacteria due to external osmotic pressure
main site of action is the cell wall of bacteria

Dosage & Administration

500mg oral dosage for urinary tract infections in adults
250 to 500mg oral dosage for respiratory tract infections in adults
250 to 500mg oral dosage for skin and soft tissue infections in adults
25 to 50mg/kg oral dosage for children
2-4 gm daily injectable dosage for adults
50-100 mg/kg daily injectable dosage for children
max daily dosage: 4 gm
dosage adjustment necessary in renal impairment

Interaction

increased risk of kidney damage with nephrotoxic drugs
enhanced renal toxicity with diuretics and probenecid

Contraindications

should not be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

gastro-intestinal disturbances
hypersensitivity phenomena
skin reactions
blood disorders
fever
jaundice
liver enzyme disturbances
reversible interstitial nephritis

Pregnancy & Lactation

safety in pregnancy not established
excreted in breast milk
should be used with caution in lactating mothers
may cause dizziness

Precautions & Warnings

prolonged use may result in superinfection
administered with care to patients hypersensitive to penicillins
may cause false positive urine glucose result
dosage adjustment necessary in renal impairment
contains lactose

Use in Special Populations

recommended doses for patients with renal impairment or on haemodialysis
higher doses may be required for chronic or severe infections
regular bacteriological and clinical monitoring required for urinary tract infections
paediatric dosages should not exceed those specified for adults

Overdose Effects

non-specific symptoms like nausea, vomiting, and diarrhoea
treatment is mainly supportive

Therapeutic Class

First generation Cephalosporins

Storage Conditions

reconstituted Suspension should be used within 7-14 days
injection solutions should be used within 2 hours
retain potency for 12 hours when stored at 5°C
do not use later than the date of expiry

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