Ceframed 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 80.00

Medicine Details

Category Details
Generic Cephradine
Company Medimet pharmaceuticals ltd
Also available as
Ceframed 250 mg capsule Ceframed 500 mg capsule Ceframed 125 mg pediatric drop

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections: sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis, otitis media
  • Lower respiratory tract infections: bronchitis, lobar pneumonia, bronchopneumonia
  • Urinary tract infections: cystitis, urethritis, pyelonephritis
  • Skin and soft tissue infections: abscess, cellulitis, furunculosis, impetigo

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in the bacterial cell wall
  • Susceptibility of both penicillinase producing and nonproducing staphylococci to Cephradine

Dosage & Administration

  • For oral administration in adults and children
  • Injectable administration for adults and children
  • Dosage adjustment in renal or hepatic function impairment

Interaction

  • Risk of kidney damage with concomitant use of nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Not to be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Rare occurrences of glossitis, heartburn, dizziness, nausea, vomiting, skin reactions, joint pains, oedema
  • Rare blood disorders, immune system disorders, psychiatric disorders, nervous system disorders, hepatic disorders, renal disorders

Pregnancy & Lactation

  • Animal studies have not demonstrated teratogenicity
  • Excretion in breast milk and caution during lactation
  • Caution about operating hazardous machinery due to dizziness

Precautions & Warnings

  • Risk of developing superinfection with prolonged use
  • Administer with care to patients hypersensitive to penicillins
  • Potential positive result in Coombs’ testing
  • Potential for false positive urine glucose result, necessitating enzyme-based tests
  • Dose adjustment in renal impairment
  • Contains lactose, not for patients with specific hereditary problems

Use in Special Populations

  • Recommended dosage adjustments in renal impairment
  • Higher doses for chronic or severe infections
  • Continued treatment for at least 2 to 3 days after symptoms have resolved
  • Regular bacteriological and clinical monitoring for urinary tract infections
  • Caution in prescribing pediatric dosages exceeding those for adults

Overdose Effects

  • Non-specific symptoms of nausea, vomiting, diarrhea, and gastric upsets
  • Supportive treatment, including gastric lavage if necessary

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepare suspension
  • Reconstituted suspension should be used within specific timeframes
  • Injection solutions should be used within specific timeframes
  • Variation in color of reconstituted solutions does not affect potency
  • Dispensation only on prescription of a registered physician

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